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Beauvericin

Cat. No. M21597
Beauvericin Structure
Size Price Availability Quantity
5mg USD 345  USD345 In stock
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Quality Control & Documentation
Biological Activity

Beauvericin is a fusarium toxin. It has a wide range of antifungal, antibacterial, protozoal and insecticidal activities, exhibits ionic properties and inhibits acyl-coenzyme: cholesterol acyltransferase activity; Apoptosis was induced by increasing intracellular calcium levels.

Chemical Information
Molecular Weight 783.95
Formula C45H57N3O9
CAS Number 26048-05-5
Form Solid
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ludmila Křžov, et al. Toxins (Basel). Feedborne Mycotoxins Beauvericin and Enniatins and Livestock Animals

[2] Alessia Bertero, et al. Toxins (Basel). Beauvericin and Enniatins: In Vitro Intestinal Effects

[3] Francesca Caloni, et al. Environ Toxicol Pharmacol. Beauvericin: The beauty and the beast

[4] Qinghua Wu, et al. Mini Rev Med Chem. Beauvericin, A Fusarium Mycotoxin: Anticancer Activity, Mechanisms, and Human Exposure Risk Assessment

[5] Beatriz Mallebrera, et al. Food Chem Toxicol. In vitro mechanisms of Beauvericin toxicity: A review

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