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NNMTi

Cat. No. M20843
NNMTi Structure
Synonym:

Compound 1k, NNMT inhibitor

Size Price Availability Quantity
5mg USD 70  USD70 In stock
10mg USD 100  USD100 In stock
25mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

NNMTi (Compound 1k, NNMT inhibitor) is a potent nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 of 1.2 μM.

Chemical Information
Molecular Weight 286.11
Formula C10H11N2.I
CAS Number 42464-96-0
Solubility (25°C) DMSO 57 mg/mL
Water 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Anna Reustle, et al. Clin Transl Med. Nicotinamide-N-methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma

[2] Andrea Dimet-Wiley, et al. Sci Rep. Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice

[3] Catherine M Sampson, et al. Sci Rep. Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice

[4] Harshini Neelakantan, et al. Biochem Pharmacol. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

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Keywords: NNMTi, Compound 1k, NNMT inhibitor supplier, inhibitors, activators

 
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