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3-Methoxybenzamide

Cat. No. M10176
3-Methoxybenzamide Structure
Synonym:

3-MBA

Size Price Availability Quantity
100mg USD 50  USD50 In stock
1g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase with Ki values of less than 2 μM and also inhibits ADP-ribosyltransferase (ADPRT).

Chemical Information
Molecular Weight 151.16
Formula C8H9NO2
CAS Number 5813-86-5
Solubility (25°C) DMSO 27 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Y Ohashi, et al. J Bacteriol. The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis

[2] M R Purnell, et al. Biochem J. Novel inhibitors of poly(ADP-ribose) synthetase

[3] T Tsujiuchi, et al. Carcinogenesis. Possible involvement of poly ADP-ribosylation in phenobarbital promotion of rat hepatocarcinogenesis

[4] G Golderer, et al. Biochem J. ADP-ribosylation of core histones and their acetylated subspecies

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Keywords: 3-Methoxybenzamide, 3-MBA supplier, Transferase, inhibitors, activators

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