Free shipping on all orders over $ 500

3-Methoxybenzamide

Cat. No. M10176
3-Methoxybenzamide Structure
Synonym:

3-MBA

Size Price Availability Quantity
100mg USD 50  USD50 In stock
1g USD 60  USD60 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase with Ki values of less than 2 μM and also inhibits ADP-ribosyltransferase (ADPRT).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 151.16
Formula C8H9NO2
CAS Number 5813-86-5
Purity 100.0%
Solubility DMSO 27 mg/mL
Storage at -20°C
References

[1] Y Ohashi, et al. J Bacteriol. The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis

[2] M R Purnell, et al. Biochem J. Novel inhibitors of poly(ADP-ribose) synthetase

[3] T Tsujiuchi, et al. Carcinogenesis. Possible involvement of poly ADP-ribosylation in phenobarbital promotion of rat hepatocarcinogenesis

[4] G Golderer, et al. Biochem J. ADP-ribosylation of core histones and their acetylated subspecies

Related Transferase Products
Ibiglustat

Ibiglustat (Venglustat) is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor.

Opicapone

Opicapone, also known as BIA 9-1067, is a novel potent and selective catechol-O-methyltransferase inhibitor (COMT inhibitor).

Adenosine Dialdehyde

Adenosine Dialdehyde (ADOX) is an adenosine analog and S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM.

Hecogenin

Hecogenin is a potent and highly selective inhibitor of UGT1A4 with an IC50 value of 1.5 μM.

Tunicamycin

Tunicamycin is a mixture of homologous nucleoside antibiotics that inhibits the UDP-HexNAc: polyprenol-P HexNAc-1-P family of enzymes.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 3-Methoxybenzamide, 3-MBA supplier, Transferase, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.