3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase with Ki values of less than 2 μM and also inhibits ADP-ribosyltransferase (ADPRT).
|Solubility (25°C)||DMSO 27 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Y Ohashi, et al. J Bacteriol. The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis
 M R Purnell, et al. Biochem J. Novel inhibitors of poly(ADP-ribose) synthetase
 T Tsujiuchi, et al. Carcinogenesis. Possible involvement of poly ADP-ribosylation in phenobarbital promotion of rat hepatocarcinogenesis
 G Golderer, et al. Biochem J. ADP-ribosylation of core histones and their acetylated subspecies
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