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Hecogenin

Cat. No. M9234
Hecogenin Structure
Synonym:

Hocogenin

Size Price Availability Quantity
20mg USD 160  USD160 In stock
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Quality Control & Documentation
Biological Activity

Hecogenin is a potent and highly selective inhibitor of UGT1A4 with an IC50 value of 1.5 μM. Hecogenin is a steroidal sapogenin which has been isolated from plants particularly from numerous Agave species.

Chemical Information
Molecular Weight 430.62
Formula C27H42O4
CAS Number 467-55-0
Solubility (25°C) DMSO
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gama KB, et al. J Nat Prod. Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate.

[2] Santos Cerqueira G, et al. Eur J Pharmacol. Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice.

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Keywords: Hecogenin, Hocogenin supplier, Transferase, inhibitors, activators

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