Hecogenin is a potent and highly selective inhibitor of UGT1A4 with an IC50 value of 1.5 μM. Hecogenin is a steroidal sapogenin which has been isolated from plants particularly from numerous Agave species.
|Storage||2-8°C, dry, protect from light, sealed|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Gama KB, et al. J Nat Prod. Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate.
 Santos Cerqueira G, et al. Eur J Pharmacol. Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice.
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