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10,12-Tricosadiynoic acid

Cat. No. M11323
10,12-Tricosadiynoic acid Structure
Size Price Availability Quantity
10mg USD 50  USD50 In stock
25mg USD 88  USD88 In stock
50mg USD 140  USD140 In stock
100mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Tricosadiynoic acid, 10,12-Tricosadiynoic acid, is A highly specific, selective, high-affinity acyl-coa oxidase-1 (ACOX1) inhibitor with oral activity. Tricosadiynoic acid can improve mitochondrial lipid and ROS metabolism and can be used to study metabolic diseases caused by high fat diet or obesity.

Chemical Information
Molecular Weight 346.55
Formula C23H38O2
CAS Number 66990-30-5
Form Solid
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Manoj Kumar Yadav, et al. Anal Biochem. Polydiacetylene vesicles acting as colorimetric sensor for the detection of plantaricin LD1

[2] Yan Liu, et al. Fish Physiol Biochem. Impaired peroxisomal fat oxidation induces hepatic lipid accumulation and oxidative damage in Nile tilapia

[3] Roberto D Ortuso, et al. Spectrochim Acta A Mol Biomol Spectrosc. The deconvolution analysis of ATR-FTIR spectra of diacetylene during UV exposure

[4] C Guo, et al. Phys Chem Chem Phys. Two-dimensional self-assembly of diacetylenic acid derivatives and their light-induced polymerization on HOPG surfaces

[5] Amornsak Chanakul, et al. J Colloid Interface Sci. Dual colorimetric response of polydiacetylene/zinc oxide nanocomposites to low and high pH

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