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Adenosine Dialdehyde

Cat. No. M9349
Adenosine Dialdehyde Structure
Synonym:

ADOX

Size Price Availability Quantity
5mg USD 88  USD88 In stock
10mg USD 133  USD133 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Adenosine Dialdehyde (ADOX) is an adenosine analog and S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 265.23
Formula C10H11N5O4
CAS Number 34240-05-6
Purity >99%
Solubility DMSO ≥ 15 mg/mL
Storage at -20°C
References

[1] Dasgupta A, et al. J Virol. Inhibition of methyltransferases results in induction of g2/m checkpoint and programmed cell death in human T-lymphotropic virus type 1-transformed cells.

[2] Chen DH, et al. J Biochem. Effects of adenosine dialdehyde treatment on in vitro and in vivo stable protein methylation in HeLa cells.

[3] O Dea RF, et al. Cancer Res. Effect of adenosine analogues on protein carboxylmethyltransferase, S-adenosylhomocysteine hydrolase, and ribonucleotide reductase activity in murine neuroblastoma cells.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Adenosine Dialdehyde, ADOX supplier, Transferase, inhibitors

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