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Adenosine Dialdehyde

Cat. No. M9349
Adenosine Dialdehyde Structure


Size Price Availability Quantity
5mg USD 88  USD88 In stock
10mg USD 133  USD133 In stock
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Biological Activity

Adenosine Dialdehyde (ADOX) is an adenosine analog and S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM.

Chemical Information
Molecular Weight 265.23
Formula C10H11N5O4
CAS Number 34240-05-6
Solubility (25°C) DMSO ≥ 15 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Dasgupta A, et al. J Virol. Inhibition of methyltransferases results in induction of g2/m checkpoint and programmed cell death in human T-lymphotropic virus type 1-transformed cells.

[2] Chen DH, et al. J Biochem. Effects of adenosine dialdehyde treatment on in vitro and in vivo stable protein methylation in HeLa cells.

[3] O Dea RF, et al. Cancer Res. Effect of adenosine analogues on protein carboxylmethyltransferase, S-adenosylhomocysteine hydrolase, and ribonucleotide reductase activity in murine neuroblastoma cells.

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Keywords: Adenosine Dialdehyde, ADOX supplier, Transferase, inhibitors, activators

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