All AbMole products are for research use only, cannot be used for human consumption.
L-NAME hydrochloride is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS, eNOS, and iNOS, with K<sub>i</sub> of 15 nM, 39 nM and 4.4 μM, respectively.
Neurotherapeutics. 2023 Dec;10.011.
Nicotinamide riboside, pterostilbene and ibudilast protect motor neurons and extend survival in ALS mice
L-NAME hydrochloride purchased from AbMole
Journal of Entomological Science. 2022 Mar 29;57 (2): 288–296.
Effect of a Nitric Oxide Synthase Inhibitor on Fighting Behavior of Male Crickets Velarifictorus aspersus (Orthoptera: Gryllidae) under Different Resource Conditions
L-NAME hydrochloride purchased from AbMole
Oxid Med Cell Longev. 2021 Jun 14;2021:6662225.
Impaired Autophagy Induced by oxLDL/ β 2GPI/anti- β 2GPI Complex through PI3K/AKT/mTOR and eNOS Signaling Pathways Contributes to Endothelial Cell Dysfunction
L-NAME hydrochloride purchased from AbMole
 |
Source | Oxid Med Cell Longev (2021). Figure 5. (Abmole Bioscience, USA) |
| Method | Cell Culture and Treatment | |
| Cell Lines | HUVECs and bEnd.3 cells | |
| Concentrations | 100 μM | |
| Incubation Time | 4 h | |
| Results | We found that LY294002, AZD5363, rapamycin, and L-NAME pretreatment could significantly upregulate the expression of LC3-II, while downregulating the expression of p62 compared with the oxLDL/β2GPI/anti-β2GPI complex alone group |
| Cell Experiment | |
|---|---|
| Cell lines | H9C2 cells |
| Preparation method | H9C2 cells were exposed to hypoxia (2%O2; 4 h) or normoxic medium (21%O2; 4 h). After 4 h, culture medium was replaced with reoxygenated medium (21%O2 2 h) for H/R and normoxia controls, or hypoxic medium (2%O2; 2 h) in the presence and absence of 50 µM MnTBap or 100 µM L-NAME and then further incubated for 2 h in the presence of MTT reagent. |
| Concentrations | 100 µM |
| Incubation time | 2 h |
| Animal Experiment | |
|---|---|
| Animal models | Male Sprague-Dawley rats |
| Formulation | distilled water |
| Dosages | 40 mg/kg/day |
| Administration | i.v. |
| Molecular Weight | 269.69 |
| Formula | C7H15N5O4.HCl |
| CAS Number | 51298-62-5 |
| Solubility (25°C) | Water ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Animal Modeling Products |
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| Sodium Thioglycolate
Sodium thioglycolate acts as reducing agent and is suitable for anaerobic and microaerophilic bacterial growth. Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo. |
| Vancomycin-d10 2TFA salt
Vancomycin-d10 2TFA salt |
| Acetic acid-d4
Acetic acid-d4 |
| Myosin H Chain Fragment, mouse acetate
Myosin H Chain Fragment, mouse acetate salt is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model. |
| Myosin H Chain Fragment, mouse
Myosin H Chain Fragment, mouse is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model. |
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