All AbMole products are for research use only, cannot be used for human consumption.
PP2 (AGL 1879) is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. PP2 (AGL 1879) strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM). PP2 (AGL 1879) also inhibits anti-CD3-stimulated tyrosine phosphorylation of human T-cells with an IC50 value of 600 nM. PP2 does not significantly affect the activity of EGFR kinase (IC50 = 480 nM), JAK2 (IC50 > 50 µM), or ZAP-70 (IC50 > 100 µM).
Int J Biol Sci. 2024 Oct 14;20(14):5695-5714.
Breast cancer-derived CAV1 promotes lung metastasis by regulating integrin α6β4 and the recruitment and polarization of tumor-associated neutrophils
PP2 purchased from AbMole
Sci Rep. 2024 Aug 29;14(1):20123.
Exploring the neuroprotective potential of Nrf2-pathway activators against annonacin toxicity
PP2 purchased from AbMole
2024 Jan.
MAPK pathway modulation and its implications in KRAS mutant lung adenocarcinoma
PP2 purchased from AbMole
Oncotarget. 2016 Feb 22.
Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo.
PP2 purchased from AbMole
-2.jpg) |
Source | Oncotarget (2016). Figure 11. Inhibitors of PI3K (LY294002), Akt (MK-2206), Src (PP2), FAK (PF573228) and mTOR (rapamycin) were purchased from Abmole Bioscience (Houston, TX, USA). |
| Method | western blot | |
| Cell Lines | MDA-MB-231 cells | |
| Concentrations | PI3K (10 µM LY294002), Akt (10 µM MK-2206) or mTOR (10 µM rapamycin) | |
| Incubation Time | 1h | |
| Results | As shown in Figure 11. Pretreating MDA-MB-231 cells with the specific inhibitors of PI3K (10 µM LY294002), Akt (10 µM MK-2206) and mTOR (10 µM rapamycin) completely abolished the LSS-induced MT1-MMP expression, indicating that the PI3K/Akt/mTOR pathway is required for LSS-induced MT1-MMP expression. |
-1.jpg) |
Source | Oncotarget (2016). Figure 1. Inhibitors of PI3K (LY294002), Akt (MK-2206), Src (PP2), FAK (PF573228) and mTOR (rapamycin) were purchased from Abmole Bioscience (Houston, TX, USA). |
| Method | Cell motility assay | |
| Cell Lines | MDA-MB-231 cells | |
| Concentrations | PI3K (10 μM LY294002), Akt (20 μM MK-2206), mTOR (10 μM rapamycin, Rap), FAK (10 μM PF573228) or Src (10 μM PP2) | |
| Incubation Time | 1h | |
| Results | "Notably, inhibitors of PI3K (LY294002), Akt (MK-2206) and mTOR (rapamycin) markedly decreased the LSS-induced wound closure activity. However, pretreatment with inhibitors of FAK (PF573228) and Src (PP2) has no effect on the LSS-induced cell motility (Figure 1B). It is suggested that PI3K, Akt and mTOR might be participated LSS-induced cell motility in an FAK and Src-independent manner. " |
| Molecular Weight | 301.77 |
| Formula | C15H16ClN5 |
| CAS Number | 172889-27-9 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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Products are for research use only. Not for human use. We do not sell to patients.
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