About 2 results found for searched term "Src-bcr-Abl" (0.127 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1701 | Dasatinib | Src-bcr-Abl |
| BMS-354825 | ||
| Dasatinib (BMS-354825) is a small molecule inhibitor of both the SRC and BCR/ABL tyrosine kinases, with IC50's for the isolated kinases of 0.55 and 3.0 nM, respectively. | ||
| M28074 | HG-7-85-01 | Src-bcr-Abl |
| HG-7-85-01 is a type II ATP competitive inhibitor of wild-type and gatekeeper mutations forms of Bcr-Abl, PDGFRα, Kit, and Src kinases. HG-7-85-01 inhibits T315I mutant Bcr-Abl kinase, KDR and RET with IC50s of 3 nM, 20 nM and 30 nM, and is only weak or no inhibition of other kinases (IC50>2 μM). HG-7-85-01 inhibits the cell proliferation, which is mediated by the induction of apoptosis, and inhibition of cell-cycle progression. | ||
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