Phorbol 12-myristate 13-acetate (PMA) is a PKC-activating phorbol ester, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM.
Theranostics. 2022 Aug 29;12(14):6242-6257.
Single-Cell RNA sequencing reveals immune cell dynamics and local intercellular communication in acute murine cardiac allograft rejection
Phorbol 12-myristate 13-acetate purchased from AbMole
Front Immunol. 2022 May 23;13:866638.
A Novel STAT3 Gain-of-Function Mutation in Fatal Infancy-Onset Interstitial Lung Disease
Phorbol 12-myristate 13-acetate purchased from AbMole
Front Immunol. 2022 Apr 28;13:883885.
TIPE2 May Target the Nrf2/HO-1 Pathway to Inhibit M1 Macrophage-Related Neutrophilic Inflammation in Asthma
Phorbol 12-myristate 13-acetate purchased from AbMole
Int J Mol Sci. 2021 Jun 14;22(12):6346.
Activity of Oritavancin and Its Synergy with Other Antibiotics against Mycobacterium abscessus Infection In Vitro and In Vivo
Phorbol 12-myristate 13-acetate purchased from AbMole
Front Immunol. 2021 Feb 25;12:620365.
Circulating Neutrophil Dysfunction in HBV-Related Acute-on-Chronic Liver Failure
Phorbol 12-myristate 13-acetate purchased from AbMole
Molecular Weight | 616.83 |
Formula | C36H56O8 |
CAS Number | 16561-29-8 |
Solubility (25°C) | DMSO 90 mg/mL Ethanol 90 mg/mL |
Storage | -20°C, protect from light |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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