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Phorbol 12-myristate 13-acetate

Cat. No. M4647
Phorbol 12-myristate 13-acetate Structure
Synonym:

PMA, TPA, 12-O-tetradecanoyl-phorbol-13-acetate

Size Price Availability Quantity
2mg USD 76.5  USD85 In stock
5mg USD 117  USD130 In stock
10mg USD 189  USD210 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Phorbol 12-myristate 13-acetate (PMA) is a PKC-activating phorbol ester, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 616.83
Formula C36H56O8
CAS Number 16561-29-8
Purity >98%
Solubility DMSO 20 mg/mL
Storage -20°C, protect from light
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Phorbol 12-myristate 13-acetate, PMA, TPA, 12-O-tetradecanoyl-phorbol-13-acetate supplier, PKC, inhibitors

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