About 32 results found for searched term "PKC" (0.085 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2850 | Midostaurin | PKC |
| PKC412 | ||
| Midostaurin (pkc412) is a multi-targeted kinase inhibitor, including PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 ranging from 80-500 nM. | ||
| M9484 | PKCβ inhibitor | PKC |
| PKC beta inhibitor | ||
| PKCβ inhibitor is a potent and selective inhibitor of PKCβ isozymes (IC50 = 5 nM and 21 nM for human PKCβII and βI). | ||
| M20591 | PKC-theta inhibitor | PKC |
| PKC-theta inhibitor inhibits PKC-θ with an IC50 of 12 nM. | ||
| M1704 | Enzastaurin | PKC |
| LY317615 | ||
| Enzastaurin inhibits PKCβ, PKCα, PKCγ and PKCε with IC50's of 0.006, 0.039, 0.083 and 0.110 µM, respectively. | ||
| M2066 | Staurosporine (AM-2282) | PKC |
| AM-2282; STS; CGP 41251 | ||
| Staurosporine (AM-2282) is a potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively. | ||
| M2192 | BMS-754807 | IGF-1R |
| Bms-754807 is a potent igf-1r /InsR reversible inhibitor with an IC50 of 1.8 nM/1.7 nM and also inhibits the activity of Met, RON, TrkA, TrkB, AurA and AurB with an IC50 value of 6,44,7,4, respectively. At 9 and 25 nM, it has almost no inhibitory activity against Flt3, Lck, MK2, PKA and PKC. | ||
| M2506 | CGP 57380 | MNK |
| CGP 57380 is potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. | ||
| M2620 | Dequalinium Chloride | PKC |
| Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM. | ||
| M2790 | K252a | PKC |
| SF 2370; Antibiotic K-252a | ||
| K252a is an inhibitor of the BDNF receptor TrkB. K-252a inhibits protein kinase with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene. | ||
| M2879 | NH125 | CaMK |
| NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor. | ||
| M2916 | PD168393 | EGFR/HER2 |
| PD168393 is an irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773; inactive against insulin, PDGFR, FGFR and PKC. | ||
| M2982 | Ro 31-8220 Mesylate | PKC |
| Bisindolylmaleimide IX Mesylate | ||
| Ro 31-8220 is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent inhibition against MAPKAP-K1b, MSK1, GSK3β and S6K1. | ||
| M3012 | SKI II | S1P Receptor |
| SphK-I2 | ||
| SKI II is a highly selective and non ATP-competitive S1P receptor inhibitor with IC50 of 0.5 μM, while exhibits no inhibitory on other kinases including PI3K, PKCα and ERK2. | ||
| M3054 | TDZD-8 | GSK-3 |
| GSK-3β Inhibitor I; NP 01139 | ||
| TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC. | ||
| M3062 | TG003 | CDK |
| TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor with IC50 of 20 nM, 200 nM, and 15 nM for Clk1, Clk2, and Clk4, respectively. No inhibitory effect on Clk3, SRPK1, SRPK2, or PKC. | ||
| M3306 | Daphnetin | PKC |
| 7,8-Dihydroxycoumarin | ||
| Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities. | ||
| M3559 | H-89 | PKA |
| Protein kinase inhibitor H-89 | ||
| H-89 is a potent PKA inhibitor with Ki of 48 nM, 10-fold selective for PKA than PKG, greater than 500-fold selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II. | ||
| M3607 | Fasudil | ROCK |
| AT-877 | ||
| Fasudil (HA-1077) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. | ||
| M3625 | Go6976 | PKC |
| Go6976 is a potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM), selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). | ||
| M3629 | LY333531 hydrochloride | PKC |
| Ruboxistaurin | ||
| LY333531 hydrochloride competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). | ||
| M3684 | Canertinib dihydrochloride | EGFR/HER2 |
| CI-1033 dihydrochloride, Canertinib 2HCl, PD-183805 dihydrochloride | ||
| Canertinib 2HCl is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. | ||
| M3694 | arcyriarubin A | PKC |
| BIM-4, bisindolylmaleimide iv | ||
| arcyriarubin A is a cell permeable protein kinase C (PKC) inhibitor. | ||
| M3799 | UCN-02 | PKC |
| UCN-02 is an inhibitor of PKC and PKA with IC50 values of 0.062 and 0.25 microM, respectively. | ||
| M3800 | CGP52421 | FLT3 |
| CGP52421 is a FLT3 inhibitor, which is also an metabolite of midostaurin (PKC412). | ||
| M3803 | Sotrastaurin | PKC |
| AEB071 | ||
| Sotrastaurin is a potent and orally-active pan-PKC inhibitor, with Kis of 0.22 nM, 0.64nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively. | ||
| M3804 | Ro 31-8220 | PKC |
| Bisindolylmaleimide IX | ||
| Ro 31-8220 is a protein kinase C inhibitor, with activity at other protein kinases (IC50 values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). | ||
| M3890 | SU9516 | CDK |
| 666837-93-0 | ||
| SU9516 is a selective CDK2 inhibtor with IC50 of 22 nM which is less potent for CDK1/CDK4(IC50=40/200 nM) and has no inhibition on PKC, EGFR, p38MAPK etc. | ||
| M3974 | Ingenol | PKC |
| (-)-Ingenol | ||
| Ingenol is a extremely weak protein kinase C (PKC) activator. Starting material for synthesis of ingenol derivatives. | ||
| M4450 | Acteoside | PKC |
| Verbascoside; Kusaginin; TJC160 | ||
| Acteoside is isolated from Acanthus mollis, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity. | ||
| M4647 | Phorbol 12-myristate 13-acetate | PKC |
| PMA, TPA, 12-O-tetradecanoyl-phorbol-13-acetate; 12,13-tetradecanoyl phorbol acetate | ||
| Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and protein kinase C (PKC) activator, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM. | ||
| M5030 | Ingenol Mebutate | PKC |
| Ingenol 3-angelate; PEP005 | ||
| Ingenol Mebutate is a diterpenoid derived from Euphorbia plant and a modulator of PKC with Ki values of 0.3, 0.105, 0.162, 0.376 and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ and PKC-ε, respectively.In addition, Ingenol Mebutate is a cell death inducer with anticancer activity.Ingenol Mebutate has been shown to be an anticancer agent. Ingenol Mebutate is also an inducer of cell death and has anticancer activity. | ||
| M5416 | TPPB | PKC |
| Activator V | ||
| A cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. Displays a marked loss of tumor promoting activity. | ||
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