PKC-theta inhibitor inhibits PKC-θ with an IC50 of 12 nM.
|Solubility (25°C)||DMSO 91 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Xin Chen, et al. Autophagy. Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis
 Simone C da Silva Rosa, et al. Autophagy. BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation
 Kole T Roybal, et al. Sci Signal. Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function
 Roland G W Staal, et al. J Neurochem. PKC theta activity maintains normal quantal size in chromaffin cells
 Amnon Altman, et al. J Biochem. Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death
|Related PKC Products|
CC-90005 is a potent, selective and orally active protein kinase C-θ (PKC-θ) inhibitor with an IC50 value of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM). CC-90005 can inhibit T cell activation via IL-2 expression.
HA-100 dihydrochloride is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase with IC50 of 4 μM, 8 μM, 12 μM and 240 μM, respectively.
2-Methoxy-1,4-naphthoquinone, isolated from the leaves of Impatiens glandulifera, specifically suppressed the expression of PKC βI, δ, and ζ in a concentration-dependent manner in Raji cells.
WAY-301398 is a inhibitor of arylamine Nacetyltransferase.
WAY-332656 is a inhibitor of Protein kinase C epsilon signaling.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.