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PKCβ inhibitor is a potent and selective inhibitor of PKCβ isozymes (IC50 = 5 nM and 21 nM for human PKCβII and βI). PKCβ inhibitor displays greater selectivity over PKCα, PKCγ, PKCε with IC50s of 331 nM, > 1 μM, and 2.8 μM, respectively.
| Molecular Weight | 411.46 |
| Formula | C24H21N5O2 |
| CAS Number | 257879-35-9 |
| Solubility (25°C) | DMSO ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] James D Phelan, et al. A multiprotein supercomplex controlling oncogenic signalling in lymphoma
[2] Ovidiu Musat, et al. DIABETIC MACULAR EDEMA
[3] Heidrun L Deissler, et al. The Protein Kinase C Inhibitor: Ruboxistaurin
[4] Thomas E Witzig, et al. Signal transduction inhibitor therapy for lymphoma
| Related PKC Products |
|---|
| Sapintoxin D
Sapintoxin D is a fluorescent phorbol ester that can be used to study the activation of protein kinase C (PKC). |
| Bryostatin 3
Bryostatin 3, a macrocyclic lactone, is a protein kinase C activator, with a Ki of 2.75 nM. |
| Ruboxistaurin mesylate
Ruboxistaurin (LY333531) mesylate is an orally active, selective and ATP competitive PKCβ inhibitor with IC50 values of 4.7 and 5.9 nM for PKCβI and PKCβII, respectively. |
| PKC β pseudosubstrate
PKC β pseudosubstrate is a selective cell-permeable inhibitor of PKC. |
| Protein Kinase C (19-31)
Protein Kinase C (19-31), a peptide inhibitor of protein kinase C (PKC), is used as protein kinase C substrate peptide for testing the protein kinase C activity. |
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Products are for research use only. Not for human use. We do not sell to patients.
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