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PKCβ inhibitor

Cat. No. M9484
PKCβ inhibitor Structure
Synonym:

PKC beta inhibitor

Size Price Availability
2mg USD 216  USD240 4-7 Days
5mg USD 360  USD400 4-7 Days
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Quality Control
  • Current batch:
  • Purity >95%
  • COA
  • MSDS
Biological Activity

PKCβ inhibitor is a potent and selective inhibitor of PKCβ isozymes (IC50 = 5 nM and 21 nM for human PKCβII and βI). PKCβ inhibitor displays greater selectivity over PKCα, PKCγ, PKCε with IC50s of 331 nM, > 1 μM, and 2.8 μM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 411.46
Formula C24H21N5O2
CAS Number 257879-35-9
Purity >95%
Solubility DMSO ≥ 50 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PKCβ inhibitor, PKC beta inhibitor supplier, PKC, inhibitors

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