All AbMole products are for research use only, cannot be used for human consumption.
RNA Synthesis IN-1 (a substitute for Actinomycin D) is an inhibitor of RNA and protein synthesis, with antibacterial and anti-tumor effects. RNA Synthesis IN-1 can inhibit the protein synthesis of bacteria, directly bind to the guanine groups of single-stranded or double-stranded DNA in the transcriptional initiation complex, inhibit the activity of DNA-dependent RNA polymerase, and interfere with the transcription process of DNA, thereby inhibiting mRNA synthesis. RNA Synthesis IN-1 inhibits DNA repair with an IC50 value of 0.42 μM.
Int J Biol Sci. 2026;22:1162-1185.
Gastrodin alleviates high fructose-induced podocyte mitochondria-mediated apoptosis by inhibiting NLRP6 to facilitate TRIM7-triggered Bok mRNA
RNA Synthesis IN-1 purchased from AbMole
Int J Biol Macromol. 2026 Feb 09;348:150816.
YTHDF2 promotes arsenic carcinogenesis through m6A-dependent SMAD7 decay and PRR5 escape from decay
RNA Synthesis IN-1 purchased from AbMole
Arterioscler Thromb Vasc Biol. 2026 Jan;46:e323986.
NAT10-Mediated ac4C-Modification Exacerbates Ferroptosis by Stabilizing HMOX1 in Deep Vein Thrombosis
RNA Synthesis IN-1 purchased from AbMole
Food Bioscience. 2026 Jan;75.
Polysaccharide from Ginkgo biloba L. endophytic bacterium Bacillus velezensis YBGRE ameliorates allergic response in food allergic RBL-2H3 cell model
RNA Synthesis IN-1 purchased from AbMole
Chin Med. 2026 Mar 18;21:00:00.000.
The IL-17 pathway mediated by m6A-modified lncRNA H19: a new mechanism for Jianpi Qingre Tongluo Prescription in repressing inflammation and improving lipid metabolism in gout arthritis.
RNA Synthesis IN-1 purchased from AbMole
Int Immunopharmacol. 2026 Jun 15;179:116621.
Inhibition of PD-L1 in tubular epithelial cells attenuates renal fibrosis by suppressing TGFβR1 and FZD6 signaling
RNA Synthesis IN-1 purchased from AbMole
Sci Rep. 2026 Jan;15:None.
Novel m5C-dependent post-transcriptional regulation of KIF11 drives lymphatic metastasis in gastric cancer
RNA Synthesis IN-1 purchased from AbMole
Cytokine. 2026 Apr 21;203:157157.
LUCAT1/PTBP1/HIF-1α feedback loop promotes T cell over-differentiation and Th1/Th2-skewed immune imbalance in sepsis via glucose metabolism
RNA Synthesis IN-1 purchased from AbMole
Cell Adh Migr. 2026 Dec;20:2650272.
N6-methyladenosine modification of NEU1 mediated by METTL3 exacerbates angiotensin II-induced atrial fibrillation.
RNA Synthesis IN-1 purchased from AbMole
Journal of Radiation Research and Applied Sciences. 2026 Apr 17;29:115310.
Mycobacterium tuberculosis escapes immunity by regulating FUS/TLR4 and metabolic reprogramming to suppress macrophage activity
RNA Synthesis IN-1 purchased from AbMole
Gene. 2026 Jan 24;986:150029.
YTHDC2-mediated RAB20 degradation regulates NLRP3 inflammasome priming to improve chronic glomerulonephritis
RNA Synthesis IN-1 purchased from AbMole
Autophagy. 2025 Oct 14; .
Lnc-HZ14 promotes LLPS-mediated SPHK1 aggrephagy degradation to suppress trophoblast cell proliferation in unexplained recurrent miscarriage
RNA Synthesis IN-1 purchased from AbMole
Sci Adv. 2025 Sep 12;11(37):eadw9519.
RNA binding protein DDX3X drives pancreatic cancer progression via the TLE2-MYL9 axis
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Sci Adv. 2025 Dec 19;11:eadz6824.
Natural variants of AGL80.5 and FPA.3 contribute to bud break timing in poplar by controlling auxin biosynthesis.
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Mol Ther. 2025 Dec 09; .
Methylated circPTK2 as a driver of fibroblast activation in pulmonary fibrosis.
RNA Synthesis IN-1 purchased from AbMole
J Immunother Cancer. 2025 Sep 22;13(9):e011893.
LTO1 and YAE1 regulate MHC-I expression via nonsense-mediated RNA decay in tumor cells
RNA Synthesis IN-1 purchased from AbMole
Cell Death Dis. 2025 Nov 23;16:852.
Downregulation of ZFP36L1 contributes to methotrexate resistance in osteosarcoma through enhanced NHEJ DNA repair mechanisms.
RNA Synthesis IN-1 purchased from AbMole
New Phytol. 2025 Jun 27; .
N4‐acetylcytidine mRNA modification regulates photosynthesis in plants
RNA Synthesis IN-1 purchased from AbMole
Clin Transl Med. 2025 Feb 26;15(3):e70249.
Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer
RNA Synthesis IN-1 purchased from AbMole
Cell Rep. 2025 Apr 23;44(5):115611.
Metabolite-dependent m6A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration
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J Transl Med. 2025 Oct 02;23(1):1043.
VISTA expressed on tumor cells is regulated by m6A and influences immune microenvironment through STAT3/CCL22 in NSCLC
RNA Synthesis IN-1 purchased from AbMole
Oncogene. 2025 Dec 08; .
circSETD3 confers radiotherapy resistance in nasopharyngeal carcinoma by attenuating ER stress-induced autophagy and apoptosis via PDIA6 upregulation.
RNA Synthesis IN-1 purchased from AbMole
Oncogene. 2025 May 26; .
m6A modification-dependent upregulation of WNT2 facilitates M2-like macrophage polarization and perpetuates malignant progression of nasopharyngeal carcinoma
RNA Synthesis IN-1 purchased from AbMole
J Med Virol. 2025 Apr 29;97(5):e70356.
Hepatitis B Virus Promotes Angiogenesis in Hepatocellular Carcinoma by Increasing m6A Modification of VEGFA mRNA via IGF2BP3
RNA Synthesis IN-1 purchased from AbMole
Clin Transl Med. 2025 Sep 26;15(10):e70483.
Radiation-induced extracellular vesicles from cancer-associated fibroblasts drive oesophageal squamous cell carcinoma metastasis via the miR-193a-3p/PTEN/Akt pathway
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Analytical Chemistry. 2025 Dec 03;Vol 97:Issue 49.
Spatial Mapping and Interactome Profiling of m6A-Modified R-Loops via Chemically Inducible Split-APEX2 Proximity Labeling
RNA Synthesis IN-1 purchased from AbMole
Cell Death Discov. 2025 Mar 13;11(1):101.
m6A-modified LINC02418 induces transcriptional and post-transcriptional modification of CTNNB1 via interacting with YBX1 and IGF2BP1 in colorectal cancer
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Mol Med. 2025 Jan 24;31(1):24.
Disrupting of IGF2BP3-stabilized CLDN11 mRNA by TNF-α increases intestinal permeability in obesity-related severe acute pancreatitis
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J Ethnopharmacol. 2025 Nov 27;357:120948.
Qiteng Xiaozhuo Granules improve chronic glomerulonephritis through promoting glomerular mesangial cell autophagy via FTO-mediated SLC7A5 m6A modification.
RNA Synthesis IN-1 purchased from AbMole
Biochem Pharmacol. 2025 Jun;236:116867.
Inhibition of METTL3 promotes mesangial cell mitophagy and attenuates glomerular damage by alleviating FOSL1 m6A modifications via IGF2BP2-dependent mechanisms
RNA Synthesis IN-1 purchased from AbMole
Cell Signal. 2025 Mar;127:111533.
tRNA methyltransferase DNMT2 promotes hepatocellular carcinoma progression and enhances Bortezomib resistance through inhibiting TNFSF10
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Biochim Biophys Acta Mol Basis Dis. 2025 Dec 01;1872:168129.
H3K9 lactylation drives FTO-mediated NRF2 suppression to exacerbate bladder epithelial ferroptosis and inflammation in diabetic bladder dysfunction.
RNA Synthesis IN-1 purchased from AbMole
J Inflamm Res. 2025 Aug 24;18:11577-11592.
NRF2 Deficiency in Bladder Epithelial Cells Owing to Ubiquitination by N6-Methyladenosine-Modified TRIM21 Induces Oxidative Stress and Inflammation to Aggravate IC/BPS
RNA Synthesis IN-1 purchased from AbMole
Sci Rep. 2025 Dec 18; .
METTL3-mediated m6A modification of TACSTD2 mRNA inhibits papillary thyroid cancer progression by activating the TNF signaling and blocking epithelial-mesenchymal transition.
RNA Synthesis IN-1 purchased from AbMole
Exp Cell Res. 2025 Jun 10; .
LncRNA USP2-AS1 Facilitates Colorectal Cancer Development Through The PHLDA2/PI3K/AKT Axis
RNA Synthesis IN-1 purchased from AbMole
Hum Cell. 2025 Feb 26;38(2):62.
MTHFD2 stabilizes LOX expression through RNA methylation modification to promote sepsis-induced acute kidney injury progression
RNA Synthesis IN-1 purchased from AbMole
BMC Cancer. 2025 May 30;25(1):970.
NAT10 inhibits the pyroptosis of laryngeal squamous cell carcinoma through ac4C modification of ELANE mRNA
RNA Synthesis IN-1 purchased from AbMole
Kaohsiung J Med Sci. 2025 Sep 27; .
Human Breast Milk‐Derived Exosomal FP671120. 4 Inhibits Macrophage M1 Polarization via Modulating the ELAVL1/Nrf2 Axis in Sepsis‐Associated Liver Injury
RNA Synthesis IN-1 purchased from AbMole
Immunol Res. 2025 Oct 15;73(1):145.
METTL14 aggravates pyroptosis in diabetic cardiomyopathy by promoting m6A modification of NLRP3
RNA Synthesis IN-1 purchased from AbMole
Int J Biochem Cell Biol. 2025 Jun 15; .
METTL5-mediated m6A modification of SLC7A11 promotes cervical cancer by inhibiting ferroptosis
RNA Synthesis IN-1 purchased from AbMole
Brain Res. 2025 Feb 01;1872:150088.
ZFP36 attenuates neuronal apoptosis and pyroptosis through inhibiting TXNIP/NLRP3 pathway in hypoxic-ischemic brain damage.
RNA Synthesis IN-1 purchased from AbMole
Biochem Biophys Res Commun. 2025 Apr 09;763:151770.
The Role of JPX in Regulating FUS/SLC7A11 Signaling Pathway Mediated Ferroptosis in Keloid Fibroblasts and its Potential in Scar Repair
RNA Synthesis IN-1 purchased from AbMole
Adv Sci (Weinh). 2024 Jan;e2207435.
Defective Homologous Recombination Repair By Up-Regulating Lnc-HZ10/Ahr Loop in Human Trophoblast Cells Induced Miscarriage
RNA Synthesis IN-1 purchased from AbMole
Adv Sci (Weinh). 2024 Sep 04;e2401118.
CRISPR/dCas13(Rx) Derived RNA N6-methyladenosine (m6A) Dynamic Modification in Plant
RNA Synthesis IN-1 purchased from AbMole
Exp Mol Med. 2024 Mar 1.
RNA m5C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer
RNA Synthesis IN-1 purchased from AbMole
Exp Mol Med. 2024 Jun 3.
METTL3-mediated pre-miR-665/DLX3 m6A methylation facilitates the committed differentiation of stem cells from apical papilla
RNA Synthesis IN-1 purchased from AbMole
J Exp Clin Cancer Res. 2024 Jun 20;471:134331.
ALKBH5 promotes non-small cell lung cancer progression and susceptibility to anti-PD-L1 therapy by modulating interactions between tumor and macrophages
RNA Synthesis IN-1 purchased from AbMole
Cancer Lett. 2024 Jun 3;596:217004.
m6A modification of lncRNA ABHD11-AS1 promotes colorectal cancer progression and inhibits ferroptosis through TRIM21/IGF2BP2/ FOXM1 positive feedback loop
RNA Synthesis IN-1 purchased from AbMole
Cancer Letters. 2024 Jun 22;16(1):2334967.
NSUN4 mediated RNA 5-methylcytosine promotes the malignant progression of glioma through improving the CDC42 mRNA stabilization
RNA Synthesis IN-1 purchased from AbMole
Pharmacol Res. 2024 Dec 01;210:107509.
METTL14-mediated m6A modification enhances USP22-ERα axis to drive breast cancer malignancy
RNA Synthesis IN-1 purchased from AbMole
Cell Death Dis. 2024 Jan;13;15(1):43.
METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner
RNA Synthesis IN-1 purchased from AbMole
Cell Death Dis. 2024 Mar 11;15(3):205.
GINS2 regulates temozolomide chemosensitivity via the EGR1/ECT2 axis in gliomas
RNA Synthesis IN-1 purchased from AbMole
Cell Death Dis. 2024 Mar 20;15(3):229.
METTL3-dependent m6A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway
RNA Synthesis IN-1 purchased from AbMole
Cell Mol Life Sci. 2024 Jun 9;81(1):253.
Poly (ADP-ribose) polymerase 1 promotes HuR/ELAVL1 cytoplasmic localization and inflammatory gene expression by regulating p38 MAPK activity
RNA Synthesis IN-1 purchased from AbMole
Int J Biol Macromol. 2024 Oct 30.
Circular RNA circWBSCR22 facilitates colorectal cancer metastasis by enhancing CHD4's protein stability
RNA Synthesis IN-1 purchased from AbMole
Free Radic Biol Med. 2024 Aug 23;224:130-143.
Prohibitin 2 confers NADPH oxidase 1-mediated cytosolic oxidative signaling to promote gastric cancer progression by ERK activation
RNA Synthesis IN-1 purchased from AbMole
Oncogene. 2024 Oct 10.
m6A-driven NAT10 translation facilitates fatty acid metabolic rewiring to suppress ferroptosis and promote ovarian tumorigenesis through enhancing ACOT7 mRNA acetylation
RNA Synthesis IN-1 purchased from AbMole
Plant Physiol. 2024 Aug 07.
N6-methyladenosine RNA modification regulates photoperiod sensitivity in cotton
RNA Synthesis IN-1 purchased from AbMole
Virus Res. 2024 Jan 2;339:199273.
Gambogic acid inhibits HBx-mediated hepatitis B virus replication by targeting the DTX1-Notch signaling pathway
RNA Synthesis IN-1 purchased from AbMole
Cell Mol Life Sci. 2024 Jun 16.
Poly (ADP-ribose) polymerase 1 promotes HuR/ELAVL1 cytoplasmic localization and inflammatory gene expression by regulating p38 MAPK activity
RNA Synthesis IN-1 purchased from AbMole
J Nutr Biochem. 2024 Jan;3:125:109563.
Dietary selenomethionine reduced oxidative stress by resisting METTL3-mediated m6A methylation level of Nrf2 to ameliorate LPS-induced liver necroptosis in laying hens
RNA Synthesis IN-1 purchased from AbMole
Cancer Cell Int. 2024 Sep 19;24(1):321.
The role of KRT7 in metastasis and prognosis of pancreatic cancer
RNA Synthesis IN-1 purchased from AbMole
J Biol Chem. 2024 Mar 25;300(5):107226.
Epstein-Barr virus suppresses N6-Methyladenosine modification of TLR9 to promote immune evasion
RNA Synthesis IN-1 purchased from AbMole
Scientific Reports. 2024 Jan ;9;14(1):904.
Hsa_circ_0081065 exacerbates IH-induced EndMT via regulating miR-665/HIF-1α signal axis and HIF-1α nuclear translocation
RNA Synthesis IN-1 purchased from AbMole
J Gastroenterol Hepatol. 2024 Oct 15.
The m6A reader IGF2BP1 contributes to the activation of hepatic stellate cells through facilitating TUBB4B mRNA stabilization
RNA Synthesis IN-1 purchased from AbMole
Plant Growth Regulation. 2024 Aug 04.
Dissecting the roles of increased mRNA m6A methylation in autotetraploidization in Stevia rebaudiana
RNA Synthesis IN-1 purchased from AbMole
Hum Mol Genet. 2024 Aug 31.
TRIM25 activates Wnt/β-catenin signalling by destabilising MAT2A mRNA to drive thoracic aortic aneurysm development
RNA Synthesis IN-1 purchased from AbMole
Mol Carcinog. 2024 Aug 02.
m6A modification of VEGFA mRNA by RBM15/YTHDF2/IGF2BP3 contributes to angiogenesis of hepatocellular carcinoma
RNA Synthesis IN-1 purchased from AbMole
Gene. 2024 Oct 01.
NIPSNAP3A regulates cellular homeostasis by modulating mitochondrial dynamics
RNA Synthesis IN-1 purchased from AbMole
Patent. CN118064581A 2024 May 24.
Patent. CN118064581A
RNA Synthesis IN-1 purchased from AbMole
Adv Sci (Weinh). 2023 Jan;10(2):e2201724.
Silencing of IRF8 Mediated by m6A Modification Promotes the Progression of T‐Cell Acute Lymphoblastic Leukemia
RNA Synthesis IN-1 purchased from AbMole
J Hazard Mater. 2023 May 6;455:131543.
BPDE exposure promotes trophoblast cell pyroptosis and induces miscarriage by up-regulating lnc-HZ14/ZBP1/NLRP3 axis
RNA Synthesis IN-1 purchased from AbMole
Plant Biotechnol J. 2023 Mar 22.
N6‐methyladenosine RNA modification regulates cotton drought response in a Ca2+ and ABA‐dependent manner
RNA Synthesis IN-1 purchased from AbMole
J Exp Clin Cancer Res. 2023 May 19;42(1):127.
Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m6A-dependent recognition of Nrf2 mRNA mediated by SND1
RNA Synthesis IN-1 purchased from AbMole
Plant Cell. 2023 Jun 27;koad189.
N4-acetylation of cytidine in (m) RNA plays essential roles in plants
RNA Synthesis IN-1 purchased from AbMole
Int J Biol Sci. 2023 Jan 1;19(2):691-704.
Upregulation of LRRC8A by m5C modification-mediated mRNA stability suppresses apoptosis and facilitates tumorigenesis in cervical cancer
RNA Synthesis IN-1 purchased from AbMole
Antiviral Res. 2023 Jan;209:105482.
Ciliatoside A, isolated from Peristrophe japonica, inhibits HBsAg expression and cccDNA transcription by inducing autophagy
RNA Synthesis IN-1 purchased from AbMole
Sci Total Environ. 2023 Sep 18;167202.
m6A methylation-mediated PGC-1α contributes to ferroptosis via regulating GSTK1 in arsenic-induced hepatic insulin resistance
RNA Synthesis IN-1 purchased from AbMole
Cell Death Dis. 2023 Sep 21;14(9):619.
Interfering with Rac1-activation during neonatal monocyte-macrophage differentiation influences the inflammatory responses of M1 macrophages
RNA Synthesis IN-1 purchased from AbMole
Front Immunol. 2023 Mar 30;14:1144774.
LRPPRC facilitates tumor progression and immune evasion through upregulation of m6A modification of PD-L1 mRNA in hepatocellular carcinoma
RNA Synthesis IN-1 purchased from AbMole
J Transl Med. 2023 Jun 23;21(1):407.
METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing
RNA Synthesis IN-1 purchased from AbMole
Oncogene. 2023 Nov 7.
Low expression of ZFP36L1 in osteosarcoma promotes lung metastasis by inhibiting the SDC4-TGF-β signaling feedback loop
RNA Synthesis IN-1 purchased from AbMole
Biomed Pharmacother. 2023 May;161:114575.
Targeting the TNF-α–TNFR interaction with EGCG to block NF-κB signaling in human synovial fibroblasts
RNA Synthesis IN-1 purchased from AbMole
Clin Epigenetics. 2023 Jul 5;15(1):109.
FTO-dependent m6A regulates muscle fiber remodeling in an NFATC1–YTHDF2 dependent manner
RNA Synthesis IN-1 purchased from AbMole
Cell Biol Toxicol. 2023 Oct;39(5):2165-2181.
AS3MT facilitates NLRP3 inflammasome activation by m6A modification during arsenic-induced hepatic insulin resistance
RNA Synthesis IN-1 purchased from AbMole
Clin Epigenetics. 2023 Jul 5;15(1):109.
FTO-dependent m6A regulates muscle fiber remodeling in an NFATC1-YTHDF2 dependent manner
RNA Synthesis IN-1 purchased from AbMole
J Cell Biochem. 2023 Feb;124(2):239-253.
IGF2BP2 enhances LincRNA01116 stability via m6A: A potential biomarker and therapeutic target for patients with pre‐eclampsia
RNA Synthesis IN-1 purchased from AbMole
Mol Biomed. 2023 Nov 17;4(1):42.
Aloperine targets lysosomes to inhibit late autophagy and induces cell death through apoptosis and paraptosis in glioblastoma
RNA Synthesis IN-1 purchased from AbMole
BMC Complementary Medicine and Therapies. 2023 Jul 1.
NAT10-mediated RNA acetylation enhances HNRNPUL1 mRNA stability to contribute cervical cancer progression
RNA Synthesis IN-1 purchased from AbMole
J Orthop Sci. 2023 May 27;S0949-2658(23)00133-1.
CircBBS9 accelerates the malignant progression of osteosarcoma through sponging miR-485-3p/HMGB1 axis
RNA Synthesis IN-1 purchased from AbMole
BioRxiv. 2023 Sep 04;556177.
Stabilization of RRBP1 mRNA via an m6A-dependent manner in prostate cancer constitutes a therapeutic vulnerability amenable to small-peptide inhibition of METTL3
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BioRxiv. 2023 Jan 28;526069.
m6A Demethylase FTO Stabilizes LINK-A to Exert Oncogenic Roles via MCM3-Mediated Cell Cycle Progression and HIF-1α Activation
RNA Synthesis IN-1 purchased from AbMole
Mol Cancer. 2022 Feb 14;21(1):49.
Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3–eIF3h interaction
RNA Synthesis IN-1 purchased from AbMole
Cells. 2022 Sep 27;11(19):3008.
m6A Modification of Long Non-Coding RNA HNF1A-AS1 Facilitates Cell Cycle Progression in Colorectal Cancer via IGF2BP2-Mediated CCND1 mRNA Stabilization
RNA Synthesis IN-1 purchased from AbMole
Cell Biol Toxicol. 2022 Feb 28;1-17.
AS3MT facilitates NLRP3 inflammasome activation by m6A modification during arsenic-induced hepatic insulin resistance
RNA Synthesis IN-1 purchased from AbMole
iScience. 2022 Nov 10;25(12):105552.
Chromodomain helicase DNA-binding domain 2 maintains spermatogonial self-renewal by promoting chromatin accessibility and mRNA stability
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Molecules. 2022 May 16;27(10):3182.
A Novel Strategy for Regulating mRNA's Degradation via Interfering the AUF1's Binding to mRNA
RNA Synthesis IN-1 purchased from AbMole
Cancer Lett. 2021 Dec 28;523:135-147.
IGFBP7-AS1 is a p53-responsive long noncoding RNA downregulated by Epstein-Barr virus that contributes to viral tumorigenesis
RNA Synthesis IN-1 purchased from AbMole
Theranostics. 2020 Apr 27;10(13):5671-5686.
SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating Snail mRNA homeostasis in hepatocellular carcinoma
RNA Synthesis IN-1 purchased from AbMole
 |
Source | Theranostics (2020 Apr). Figure 5. Actinomycin D (Abmole Bioscience, US) |
| Method | RNA decay assay | |
| Cell Lines | MHCC97H and HepG2 cells | |
| Concentrations | 5 μg/mL | |
| Incubation Time | - | |
| Results | We next sought to assess the RNA decay rate in Mettl3-WT and Mettl3-KR cells treated with the transcription inhibitor actinomycin D to block new RNA synthesis. Snail mRNA expression was decreased, and the Snail mRNA half-lives were significantly shortened in SUMO-mutant Mettl3 cells |
| Molecular Weight | 1255.5 |
| Solubility (25°C) | DMSO ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related DNA/RNA Synthesis Products |
|---|
| Mizoribine
Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. Mizoribine inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively. |
| CDDP
Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells. |
| Raltitrexed
Raltitrexed is an inhibitor of thymidylate synthase used in cancer chemotherapy. |
| Carmofur
Carmofur is a pyrimidine analog that is a prodrug of 5-fluorouracil (5-FU), which inhibits DNA Synthesis and has better antiproliferative activity than 5-FU. Carmofur is an inhibitor of Acidic Ceramidase (ASAH1) and a potential lead compound for non-cancer diseases such as Krabbe disease, acute lung injury (ALI), Parkinson's disease (PD), dementia, etc. Carmofur also has antifungal and antimicrobial properties. |
| 5-Fluorouracil
5-Fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
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