Lipopolysaccharides

Biological Activity

Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharide is a highly immunogenic antigen which can enhance immune responses. This product is derived from Escherichia coli O55:B5. Its potency is more than 500,000 EU/mg.

Product Citations

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  Microbiol Spectr. 2025 Feb 4;13(2):e0158024.

  Neospora caninum infection specifically suppresses the expression of a host lncRNA XR_001919077.1 to facilitate parasite propagation by modulating host cell mitochondrial function and autophagy
  Lipopolysaccharides purchased from AbMole

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  J Thorac Oncol. 2024 Aug;19(8):1186-1200.

  EGFR Oncogenic Mutations in NSCLC Impair Macrophage Phagocytosis and Mediate Innate Immune Evasion Through Up-Regulation of CD47
  Lipopolysaccharides purchased from AbMole

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  Bioact Mater. 2024 Mar 20;37:132-15.

  Immune-defensive microspheres promote regeneration of the nucleus pulposus by targeted entrapment of the inflammatory cascade during intervertebral disc degeneration
  Lipopolysaccharides purchased from AbMole

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  ACS Nano. 2024 Dec 21.

  Biomimetic “Trojan Horse” Fibers Modulate Innate Immunity Cascades for Nerve Regeneration
  Lipopolysaccharides purchased from AbMole

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  Crit Care. 2024 Jan;28(1):36.

  The protective effect of apolipoprotein H in paediatric sepsis
  Lipopolysaccharides purchased from AbMole

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  Int J Nanomedicine. 2024 Nov 15;19:11941-11956.

  Therapeutic Potential of Ginger Exosome-Like Nanoparticles for Alleviating Periodontitis-Induced Tissue Damage
  Lipopolysaccharides purchased from AbMole

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  Int Immunopharmacol. 2024 Apr 20;131:111883.

  Local thiamet-G delivery by a thermosensitive hydrogel confers ischemic cardiac repair via myeloid M2-like activation in a STAT6 O-GlcNAcylation-dependent manner
  Lipopolysaccharides purchased from AbMole

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  Ind Crops Prod. 2024 Sep 24.

  Role of substitution degree in thiol-modified hyaluronic acid in enhancing the physical stability of curcumin-loaded zein nanoparticles
  Lipopolysaccharides purchased from AbMole

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  J Ethnopharmacol. 2024 Jan 30;319(Pt 3):117337.

  Essential Oil from Ligusticum Chuanxiong Hort. Alleviates Lipopolysaccharide-Induced Neuroinflammation: Integrating Network Pharmacology and Molecular
  Lipopolysaccharides purchased from AbMole

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  Int Immunopharmacol. 2024 Jul 03;22(1):37.

  Hypoxia-induced Semaphorin 3A promotes the development of endometriosis through regulating macrophage polarization
  Lipopolysaccharides purchased from AbMole

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  Heliyon. 2024 May 16;10(10):e30708.

  Chronotherapy involving rosiglitazone regulates the phenotypic switch of vascular smooth muscle cells by shifting the phase of TNF-α rhythm through triglyceride accumulation in macrophages
  Lipopolysaccharides purchased from AbMole

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  J Virol Methods. 2024 Mar 28;327:114921.

  Optimal conditions for adenoviral transduction of immature dendritic cells without affecting the tolerogenic activity of DC-based immunotherapy
  Lipopolysaccharides purchased from AbMole

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  Parasit Vectors. 2024 Nov 29;17(1):495.

  The microneme protein1 (MIC1) of Chinese 1 Toxoplasma regulates pyroptosis through the TLR4/NLRP3 pathway in macrophages
  Lipopolysaccharides purchased from AbMole

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  J Orthop Surg Res. 2024 Apr 08;19(1):230.

  SP1 transcriptionally activates HTR2B to aggravate traumatic spinal cord injury by shifting microglial M1/M2 polarization
  Lipopolysaccharides purchased from AbMole

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  JPI. 2024 Jan-Feb;67(1):p 47-56.

  Fatty Acid Binding Protein-4 Silencing Inhibits Ferroptosis to Alleviate Lipopolysaccharide-induced Injury of Renal Tubular Epithelial Cells by Blocking Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling
  Lipopolysaccharides purchased from AbMole

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  EBioMedicine. 2023 Dec 6;99:104904.

  Multi-omics analyses reveal bacteria and catalase associated with keloid disease
  Lipopolysaccharides purchased from AbMole

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  Food Chemistry. 2023 Dec 15;136858.

  Thiol-modified hyaluronic acid improves the physical stability of curcumin-zein nanoparticles by forming disulfide bonds with zein
  Lipopolysaccharides purchased from AbMole

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  Biomed Pharmacother. 2023 May;161:114575.

  Targeting the TNF-α–TNFR interaction with EGCG to block NF-κB signaling in human synovial fibroblasts
  Lipopolysaccharides purchased from AbMole

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  Front Immunol. 2022 Aug 15;13:914381.

  YAP9/A20 complex suppresses proinflammatory responses and provides novel anti-inflammatory therapeutic potentials
  Lipopolysaccharides purchased from AbMole

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  Oxid Med Cell Longev. 2022 Apr 16;2022:4505513.

  Nrf2-Mediated Ferroptosis Inhibition Exerts a Protective Effect on Acute-on-Chronic Liver Failure
  Lipopolysaccharides purchased from AbMole

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  J Funct Foods. 2022 Aug;Volume 95, 105191.

  Royal jelly attenuates LPS-induced immune dysfunction of dendritic cells via Nrf2/HO-1 axis
  Lipopolysaccharides purchased from AbMole

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  Mol Med Rep. 2022 Jul;26(1):220.

  Tranilast attenuates lipopolysaccharide‑induced lung injury via the CXCR4/JAK2/STAT3 signaling pathway
  Lipopolysaccharides purchased from AbMole

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  Can Respir J. 2022 Jul 31;2022:8433960.

  Dexmedetomidine Attenuates LPS-Stimulated Alveolar Type II Cells' Injury through Upregulation of miR-140-3p and Partial Suppression of PD-L1 Involving Inactivating JNK-Bnip3 Pathway
  Lipopolysaccharides purchased from AbMole

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  Mar Drυgs. 2020 Oct 28;18(11):538.

  Immunostimulatory Effects of Polysaccharides from Spirulina platensis In Vivo and Vitro and Their Activation Mechanism on RAW246.7 Macrophages
  Lipopolysaccharides purchased from AbMole

Chemical Information

Solubility (25°C)	Water ≥ 5 mg/mL
Storage	2-8°C, protect from light, sealed

References

[1] Hai-Ping Zhu, et al. Mol Med Rep. Regulatory mechanism of NOV/CCN3 in the inflammation and apoptosis of lung epithelial alveolar cells upon lipopolysaccharide stimulation

[2] Lei Yang, et al. Am J Transl Res. Resveratrol alleviates sepsis-induced acute lung injury by suppressing inflammation and apoptosis of alveolar macrophage cells

[3] H T L Lai, et al. Poult Sci. Effects of Repeated Intratracheally Administered Lipopolysaccharide on Primary and Secondary Specific Antibody Responses and on Body Weight Gain of Broilers.

[4] D S Kabanov, et al. Biochemistry (Mosc). Structural Analysis of Lipopolysaccharides From Gram-negative Bacteria.