Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharide is a highly immunogenic antigen which can enhance immune responses. This product is derived from Escherichia coli O55:B5. Its potency is more than 500,000 EU/mg.
Mol Med Rep. 2022 Jul;26(1):220.
Tranilast attenuates lipopolysaccharide‑induced lung injury via the CXCR4/JAK2/STAT3 signaling pathway
Lipopolysaccharides purchased from AbMole
Front Immunol. 2022 Aug 15;13:914381.
YAP9/A20 complex suppresses proinflammatory responses and provides novel anti-inflammatory therapeutic potentials
Lipopolysaccharides purchased from AbMole
J Funct Foods. 2022 Aug;Volume 95, 105191.
Royal jelly attenuates LPS-induced immune dysfunction of dendritic cells via Nrf2/HO-1 axis
Lipopolysaccharides purchased from AbMole
Can Respir J. 2022 Jul 31;2022:8433960.
Dexmedetomidine Attenuates LPS-Stimulated Alveolar Type II Cells' Injury through Upregulation of miR-140-3p and Partial Suppression of PD-L1 Involving Inactivating JNK-Bnip3 Pathway
Lipopolysaccharides purchased from AbMole
Oxid Med Cell Longev. 2022 Apr 16;2022:4505513.
Nrf2-Mediated Ferroptosis Inhibition Exerts a Protective Effect on Acute-on-Chronic Liver Failure
Lipopolysaccharides purchased from AbMole
Mar Drυgs. 2020 Oct 28;18(11):538.
Immunostimulatory Effects of Polysaccharides from Spirulina platensis In Vivo and Vitro and Their Activation Mechanism on RAW246.7 Macrophages
Lipopolysaccharides purchased from AbMole
Solubility (25°C) | Water ≥ 5 mg/mL |
Storage | 2-8°C, dry, protect from light, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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