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Puromycin dihydrochloride

Cat. No. M3637
Puromycin dihydrochloride Structure

Puromycin 2HCl

Size Price Availability Quantity
5mg USD 40.5  USD45 In stock
10mg USD 57.6  USD64 In stock
25mg USD 90  USD100 In stock
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Quality Control
Biological Activity

Puromycin dihydrochloride is a protein synthesis inhibitor. Puromycin 2HCl leads to the premature release of polypeptide chains as polypeptidyl purine derivatives. Analog of the 3' end of aminoacyl-tRNA. Puromycin dihydrochloride Inhibits translation in both in vitro and in vivo systems. Puromycin dihydrochloride inhibits the transport of proteins into the mitochondria in vitro. Puromycin inhibits protein import into mitochondria by interfering with an ATP-dependent step in the import process and that the ATP-dependent component in the reaction is located inside the inner mitochondrial membrane.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 544.43
Formula C22H29N7O5.2HCl
CAS Number 58-58-2
Purity >98%
Solubility Water ≥ 27 mg/mL
Storage at -20°C

Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction.
Price J, et al. Biochim Biophys Acta. 1993 Jul 25;1150(1):89-97. PMID: 8334141.

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Keywords: Puromycin dihydrochloride, Puromycin 2HCl supplier, DNA/RNA Synthesis, inhibitors

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