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DAPI dihydrochloride

Cat. No. M5106
DAPI dihydrochloride Structure
Synonym:

4',6-Diamidino-2-phenylindole dihydrochloride

Size Price Availability Quantity
5mg USD 45  USD45 In stock
10mg USD 60  USD60 In stock
25mg USD 118  USD118 In stock
50mg USD 215  USD215 In stock
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Quality Control & Documentation
Biological Activity

DAPI dihydrochloride is a fluorescent stain by binding in the minor grove of A-T rich sequences of DNA.

Product Citations
Chemical Information
Molecular Weight 350.25
Formula C16H17Cl2N5
CAS Number 28718-90-3
Solubility (25°C) Water 5 mg/mL (Need ultrasonic)
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qunxiong Wu, et al. Reprod Sci. LncRNA HOXA-AS2 Activates the Notch Pathway to Promote Cervical Cancer Cell Proliferation and Migration

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Keywords: DAPI dihydrochloride, 4',6-Diamidino-2-phenylindole dihydrochloride supplier, Fluorescent Dye, inhibitors, activators

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