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HEPES

Cat. No. M6793
HEPES Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50g USD 70  USD70 In stock
100g USD 120  USD120 In stock
250g USD 220  USD220 In stock
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Quality Control & Documentation
Biological Activity

HEPES is a multi purpose buffer used in biological research.

Product Citations
Chemical Information
Molecular Weight 238.3
Formula C8H18N2O4S
CAS Number 7365-45-9
Solubility (25°C) Water ≥ 200 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Pierce, et al. J Med Chem. Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase.

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