HEPES

Biological Activity

HEPES is a multi purpose buffer used in biological research.

Product Citations

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  Nat Commun. 2021 Jun 23;12(1):3896.

  Single cell derived mRNA signals across human kidney tumors
  HEPES purchased from AbMole

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  EMBO Mol Med. 2021 Jul 7;13(7):e13067.

  Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis
  HEPES purchased from AbMole

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  Adv Healthc Mater. 2021 Aug;10(16):e2100821.

  Extracellular Matrix Stiffness Regulates DNA Methylation by PKCα-Dependent Nuclear Transport of DNMT3L
  HEPES purchased from AbMole

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  Cell Death Dis. 2021 Feb 15;12(2):179.

  Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors
  HEPES purchased from AbMole

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  Cells. 2021 Feb 18;10(2):430.

  Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis
  HEPES purchased from AbMole

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  Nat Commun. 2020 Aug 27;11(1):4279.

  Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer
  HEPES purchased from AbMole

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  Cell Stem Cell. 2020 Nov 5;27(5):840-851.e6.

  Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo
  HEPES purchased from AbMole

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  NAS. 2020 Jun.

  Multiscale activity imaging in mammary gland reveals how oxytocin enables lactation
  HEPES purchased from AbMole

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  Sci Rep. 2020 Jul 31;10(1):12991.

  Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis
  HEPES purchased from AbMole

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  Environ Health Perspect. 2020 Jun;128(6):67008.

  Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation
  HEPES purchased from AbMole

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  J Virol. 2020 Feb 14;94(5):e01791-19.

  Targeting Kaposi's Sarcoma-Associated Herpesvirus ORF21 Tyrosine Kinase and Viral Lytic Reactivation by Tyrosine Kinase Inhibitors Approved for Clinical Use
  HEPES purchased from AbMole

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information

References

Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase.
Pierce, et al. J Med Chem. 2008;51: 1972. PMID: 18290603.