All AbMole products are for research use only, cannot be used for human consumption.
FB23-2 is a potent and selective FTO inhibitor with an IC50 of 2.6 μM, directly binds to FTO and selectively inhibit FTO's m6A demethylase activity. FB23-2 dramatically suppresses proliferation and promotes the differentiation/apoptosis of human acute myeloid leukemia (AML) cell line cells and primary blast AML cells in vitro. Moreover, FB23-2 significantly inhibits the progression of human AML cell lines and primary cells in xeno-transplanted mice.
Adv Sci (Weinh). 2023 Jan;10(2):e2201724.
Silencing of IRF8 Mediated by m6A Modification Promotes the Progression of T‐Cell Acute Lymphoblastic Leukemia
FB23-2 purchased from AbMole
Clin Epigenetics. 2023 Jul 5;15(1):109.
FTO-dependent m6A regulates muscle fiber remodeling in an NFATC1–YTHDF2 dependent manner
FB23-2 purchased from AbMole
Clin Epigenetics. 2023 Jul 5;15(1):109.
FTO-dependent m6A regulates muscle fiber remodeling in an NFATC1-YTHDF2 dependent manner
FB23-2 purchased from AbMole
| Molecular Weight | 392.24 |
| Formula | C18H15Cl2N3O3 |
| CAS Number | 2243736-45-8 |
| Solubility (25°C) | DMSO ≥ 45 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
| Related FTO Products |
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| FTO-IN-1 TFA
FTO-IN-1 TFA is a fat mass and obesity-associated enzyme (FTO) inhibitor, with an IC50 of <1 μM. |
| Ethyl LipotF
Ethyl LipotF is a selective FTO inhibitor that significant increases modified N6-methyladenosine (m6A) levels in HeLa cells in a concentration-dependent manner. |
| ZLD115
ZLD115 is a FB23-derivated inhibitor of Fat Mass and Obesity-associated Protein (FTO). |
| Meclofenamic acid sodium hydrate
Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively. |
| Meclofenamic acid
Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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