About 30 results found for searched term "FTO" (0.055 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1854 | VX-770 (Ivacaftor) | CFTR |
| Ivacaftor | ||
| VX-770 (Ivacaftor) is a first-in-class potentiator of CFTR, which targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. | ||
| M2102 | VX-809 | CFTR |
| Lumacaftor | ||
| VX-809 is a CFTR corrector that improves CFTR processing and maturation in the cell. | ||
| M3128 | VX-661 | CFTR |
| Tezacaftor | ||
| Vx-661 is the second F508del CFTR correction compound that assists the CFTR protein to reach the cell surface. | ||
| M3457 | Naftopidil | Adrenergic Receptor |
| KT-611; BM-15275 | ||
| Naftopidil is a selective α1-adrenergic receptor antagonist or alpha blocker with a Ki of 58.3 nM. | ||
| M4341 | Schaftoside | TLR |
| Schaftoside is a flavonoid found in a variety of Chinese herbs such as Eleusine indica. Schaftoside inhibited TLR4 and Myd88 expression. Schaftoside also reduced Drp1 expression and phosphorylation, and reduced mitochondrial division. | ||
| M4342 | Isoshaftoside | Antibiotic |
| Isoschaftosid is a C-glycosylated flavonoid extracted from the root exudate of Desmodium uncinatum, which can inhibit the growth of s. Hermonthica embryo. | ||
| M10162 | Elexacaftor (VX-445) | CFTR |
| VX-445 | ||
| Elexacaftor (VX-445) is a next-generation modulator of cystic fibrosis transmembrane conductance regulator (CFTR). | ||
| M13430 | Ziftomenib | Epigenetic Reader Domain |
| KO-539; ziftomenibum | ||
| Ziftomenib (KO-539) is an inhibitor of menin-MLL interaction with antitumor activity. | ||
| M14206 | Nesolicaftor | CFTR |
| PTI-428 | ||
| Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier. | ||
| M18826 | Neoschaftoside | Others |
| Neoschaftoside | ||
| M20391 | Naftopidil DiHCl | Adrenergic Receptor |
| KT-611 | ||
| Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively. | ||
| M21140 | Icenticaftor | CFTR |
| QBW251 | ||
| Icenticaftor (QBW251) is an oral enhancer of the cystic fibrosis transmembrane conductance regulator (CFTR) channel with an EC50 of 79 nM for F508del and 497 nM for G551D CFTR. Icenticaftor can be used in chronic obstructive pulmonary disease (COPD) and cystic fibrosis studies. | ||
| M22479 | Lisaftoclax | Bcl-2 |
| APG-2575; Bcl-2/Bcl-xl inhibitor 1 | ||
| Lisaftoclax (APG-2575) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. | ||
| M24821 | Eftozanermin alfa | Apoptosis |
| ABBV-621 | ||
| Eftozanermin alfa (ABBV-621) is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa induces apoptosis in tumor cells by activation of death receptors 4/5. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies. | ||
| M29003 | Olacaftor | CFTR |
| VX-440 | ||
| Olacaftor (VX-440) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408. | ||
| M29021 | Galicaftor | CFTR |
| ABBV-2222; GLPG-2222 | ||
| Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. Galicaftor can be used for cystic fibrosis research. | ||
| M29207 | Posenacaftor | CFTR |
| PTI-801 | ||
| Posenacaftor (PTI-801) is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF). | ||
| M29208 | Posenacaftor sodium | CFTR |
| PTI-801 sodium | ||
| Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF). | ||
| M29688 | Ceftobiprole medocaril sodium | Antibiotic |
| BAL5788 sodium | ||
| Ceftobiprole medocaril (BAL5788) sodium is the parenteral proagent of Ceftobiprole. Ceftobiprole is a parenteral pyrrolidinone cephalosporin. Ceftobiprole is a broad-spectrum cephalosporin with high levels of in vitro activity against methicillin- (MRSA) and vancomycin-resistant staphylococci (VRSA) and penicillin-resistant streptococci. Ceftobiprole also inhibits gram-positive and gram-negative pathogens. | ||
| M30013 | Ceftobiprole medocaril | Antibiotic |
| BAL5788 | ||
| Ceftobiprole medocaril (BAL5788) is the parenteral proagent of Ceftobiprole. Ceftobiprole is a parenteral pyrrolidinone cephalosporin. Ceftobiprole is a broad-spectrum cephalosporin with high levels of in vitro activity against methicillin- (MRSA) and vancomycin-resistant staphylococci (VRSA) and penicillin-resistant streptococci. Ceftobiprole also inhibits gram-positive and gram-negative pathogens. | ||
| M41094 | Ceftolozane sulfate | Antibiotic |
| Ceftolozane (CXA-101) sulfate is an antipseudomonal cephalosporin. | ||
| M50208 | Vanzacaftor | CFTR |
| VX-121 | ||
| Vanzacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector that increases the number of CFTR proteins on the cell surface by facilitating the processing and transport of CFTR proteins, and can be used in cystic fibrosis (CF) related studies. | ||
| M50209 | Deutivacaftor | CFTR |
| CTP-656 | ||
| Deutivacaftor is a potentiator that improves the flow of salt and water across cell membranes by increasing the probability of channel opening of CFTR proteins delivered to the cell surface.Deutivacaftor can be used in cystic fibrosis (CF) related studies. | ||
| M54652 | Bamocaftor | CFTR |
| VX-659 | ||
| Bamocaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector that restores F508del-CFTR protein function.Bamocaftor can be used in cystic fibrosis-related studies. | ||
| M54658 | Ivacaftor hydrate | CFTR |
| VX-770 hydrate | ||
| Ivacaftor hydrate is an orally active cystic fibrosis transmembrane conductance regulator (CFTR) enhancer for cystic fibrosis related studies. | ||
| M54659 | (R)-Elexacaftor | CFTR |
| (R)-VX-445 | ||
| (R)-Elexacaftor is an enantiomer of Elexacaftor and a corrector of cystic fibrosis transmembrane conductance regulator (CFTR) with an EC50 value of 0.29 μM for CFTR dF508. | ||
| M54664 | (R)-Olacaftor | CFTR |
| (R)-VX-440 | ||
| (R)-Olacaftor is a cystic fibrosis transmembrane regulator (CFTR) modulator that can be used in cystic fibrosis (CF) related studies. | ||
| M54666 | (R)-Posenacaftor sodium | CFTR |
| (R)-PTI-801 sodium | ||
| (R)-Posenacaftor sodium is the R-enantiomer of Posenacaftor and a cystic fibrosis transmembrane regulatory protein (CFTR) modulator that corrects the folding and transport of CFTR proteins.Posenacaftor is used in studies related to cystic fibrosis (CF). | ||
| M54693 | Ceftobiprole | Antibiotic |
| Ro 63-9141; BAL 9141 | ||
| Ceftobiprole is a broad-spectrum cephalosporin with rapid bactericidal activity against Gram-positive bacteria such as Staphylococcus aureus, including methicillin-resistant strains (MRSA), and Gram-negative bacteria, with a MIC90 value of 2 μg/mL against MRSA. | ||
| M54649 | Navocaftor | CFTR |
| GLPG 3067; ABBV-3067 | ||
| Navocaftor is a cystic fibrosis transmembrane regulator (CFTR) modulator. | ||
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