Vanzacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector that increases the number of CFTR proteins on the cell surface by facilitating the processing and transport of CFTR proteins, and can be used in cystic fibrosis (CF) related studies.
Molecular Weight | 617.76 |
Formula | C32H39N7O4S |
CAS Number | 2374124-49-7 |
Form | Solid |
Storage | -20°C |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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