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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M2102 | VX-809 | VX-809 is a CFTR corrector that improves CFTR processing and maturation in the cell. |
| M21215 | CP-628006 | The CFTR potentiator CP-628006 enhances CFTR function in cystic fibrosis patient-derived air chamber cells by a mechanism of action different from that of existing potentiators such as ivacaftor. |
| M21140 | Icenticaftor | Icenticaftor (QBW251) is an oral enhancer of the cystic fibrosis transmembrane conductance regulator (CFTR) channel with an EC50 of 79 nM for F508del and 497 nM for G551D CFTR. Icenticaftor can be used in chronic obstructive pulmonary disease (COPD) and cystic fibrosis studies. |
| M21132 | NJH-2-057 | NJH-2-057 is a conjugate of the deubiquitinase OTUB1 covalent ligand-linked lumacaftor, which stabilizes mutant CFTR proteins in cells. |
| M21104 | GLPG2451 | GLPG2451 is an enhancer of cystic fibrosis transmembrane conductance regulator (CFTR) and effectively enhances cryo-rescued F508del CFTR with an EC50 of 11.1 nM. |
| M20965 | FDL169 | FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein. |
| M14206 | Nesolicaftor | Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier. |
| M14205 | BPO-27 racemate | BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM. |
| M10162 | Elexacaftor (VX-445) | Elexacaftor (VX-445) is a next-generation modulator of cystic fibrosis transmembrane conductance regulator (CFTR). |
| M10103 | Plecanatide | Plecanatide is a structural analog of human uroguanylin, and similarly to uroguanylin, plecanatide functions as a guanylate cyclase-C (GC-C) agonist. |
| M9097 | GLPG1837 | GLPG1837 (ABBV-974) is a novel CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively. |
| M6754 | GlyH 101 | GlyH 101 is a reversible, voltage-dependent CFTR chloride channel blocker. |
| M3147 | PPQ-102 | PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50 approximately 90 nM. |
| M3128 | VX-661 | Vx-661 is the second F508del CFTR correction compound that assists the CFTR protein to reach the cell surface. |
| M2774 | IOWH032 | IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 1/2. |
| M2504 | CFTRinh-172 | CFTRinh-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. |
| M2102 | VX-809 | VX-809 is a CFTR corrector that improves CFTR processing and maturation in the cell. |
| M1923 | Lonidamine | Lonidamine is a novel CFTR open channel blocker with an IC50 of 0.85 mM, which inhibits aerobic glycolysis in cancer cells. |
| M1854 | VX-770 (Ivacaftor) | VX-770 (Ivacaftor) is a potentiator of CFTR, which targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. |
| M1771 | PTC124 (Ataluren) | Ataluren (PTC124) is a novel, orally available small molecular CFTR-G542X nonsense allele inhibitor. |
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