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CFTR Cystic fibrosis transmembrane conductance regulator

Cat.No.  Name Information
M2102 VX-809 VX-809 is a CFTR corrector that improves CFTR processing and maturation in the cell.
M10162 Elexacaftor (VX-445) Elexacaftor (VX-445) is a next-generation modulator of cystic fibrosis transmembrane conductance regulator (CFTR).
M9097 GLPG1837 GLPG1837 (ABBV-974) is a novel CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
M6754 GlyH 101 GlyH 101 is a reversible, voltage-dependent CFTR chloride channel blocker.
M3147 PPQ-102 PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50 approximately 90 nM.
M3128 VX-661 Vx-661 is the second F508del CFTR correction compound that assists the CFTR protein to reach the cell surface.
M2774 IOWH032 IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 1/2.
M2504 CFTRinh-172 CFTRinh-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.
M1923 Lonidamine Lonidamine is a novel CFTR open channel blocker with an IC50 of 0.85 mM, which inhibits aerobic glycolysis in cancer cells.
M1854 VX-770 (Ivacaftor) VX-770 (Ivacaftor) is a first-in-class potentiator of CFTR, which targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
M1771 PTC124 (Ataluren) Ataluren (PTC124) is a novel, orally available small molecular CFTR-G542X nonsense allele inhibitor.
M42173 CFTR corrector 11 CFTR corrector 11 is a CFTR corrector.
M42172 CRF1 receptor antagonist-1 CRF1 receptor antagonist-1 is a CRF1 receptor antagonist.
M42171 CFTR corrector 12 CFTR corrector 12 is a bithiazole derivative, serving as CFTR corrector.
M29368 GLPG-3221  GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis.
M29208 Posenacaftor sodium Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF).
M29207 Posenacaftor Posenacaftor (PTI-801) is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF).
M29021 Galicaftor Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. Galicaftor can be used for cystic fibrosis research.
M29020 CFTR corrector 4  CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis.
M29003 Olacaftor Olacaftor (VX-440) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408.




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