| Cat.No. | Name | Information |
|---|---|---|
| M2102 | VX-809 | VX-809 is a CFTR corrector that improves CFTR processing and maturation in the cell. |
| M10162 | Elexacaftor (VX-445) | Elexacaftor (VX-445) is a next-generation modulator of cystic fibrosis transmembrane conductance regulator (CFTR). |
| M9097 | GLPG1837 | GLPG1837 (ABBV-974) is a novel CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively. |
| M6754 | GlyH 101 | GlyH 101 is a reversible, voltage-dependent CFTR chloride channel blocker. |
| M3147 | PPQ-102 | PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50 approximately 90 nM. |
| M3128 | VX-661 | Vx-661 is the second F508del CFTR correction compound that assists the CFTR protein to reach the cell surface. |
| M2774 | IOWH032 | IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 1/2. |
| M2504 | CFTRinh-172 | CFTRinh-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. |
| M1923 | Lonidamine | Lonidamine is a novel CFTR open channel blocker with an IC50 of 0.85 mM, which inhibits aerobic glycolysis in cancer cells. |
| M1854 | VX-770 (Ivacaftor) | VX-770 (Ivacaftor) is a first-in-class potentiator of CFTR, which targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. |
| M1771 | PTC124 (Ataluren) | Ataluren (PTC124) is a novel, orally available small molecular CFTR-G542X nonsense allele inhibitor. |
| M42173 | CFTR corrector 11 | CFTR corrector 11 is a CFTR corrector. |
| M42172 | CRF1 receptor antagonist-1 | CRF1 receptor antagonist-1 is a CRF1 receptor antagonist. |
| M42171 | CFTR corrector 12 | CFTR corrector 12 is a bithiazole derivative, serving as CFTR corrector. |
| M29368 | GLPG-3221 | GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis. |
| M29208 | Posenacaftor sodium | Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF). |
| M29207 | Posenacaftor | Posenacaftor (PTI-801) is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF). |
| M29021 | Galicaftor | Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. Galicaftor can be used for cystic fibrosis research. |
| M29020 | CFTR corrector 4 | CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis. |
| M29003 | Olacaftor | Olacaftor (VX-440) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408. |
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