Free shipping on all orders over $ 500

PG 01

Cat. No. M7128

All AbMole products are for research use only, cannot be used for human consumption.

PG 01 Structure
Size Price Availability Quantity
5mg USD 450  USD450 In stock
10mg USD 720  USD720 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

PG 01 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. Corrects gating defects of CFTR mutants such as ΔF508 (Ka = 0.3 μM), E193K and G970R (Kd values are 0.22 μM and 0.45 μM respectively). Increases ΔF508-CFTR Cl- currents in the presence of forskolin; displays no effect on Ca2+-activated Cl- current.

Chemical Information
Molecular Weight 439.55
Formula C28H29N3O2
CAS Number 853138-65-5
Solubility (25°C) DMSO 43.95 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Herschhorn, et al. Nat Chem Biol. A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry.

Related CFTR Products
GLPG2737 

GLPG2737 is a potent CFTR type 2 corrector, and GLPG2737 can be used in combination with a type 1 co-corrector in the study of cystic fibrosis.

NJH-2-057 

NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds ΔF508-CFTR.

GLPG2737

GLPG2737 is a novel potent Type 2 corrector of CFTR. GLPG2737 showed high permeability both in MDCKII-MDRI and Caco-2 cells, with low efflux allowing an elevated absorbed fraction FaxFg and a dose proportional increase in exposure in rat from a dose of 5 to 300 mg/kg, despite a low aqueous thermodynamic solubility.

UCCF-853

UCCF-853 is a cystic fibrosis transmembrane regulatory protein (CFTR) modulator.

(R)-Posenacaftor sodium

(R)-Posenacaftor sodium is the R-enantiomer of Posenacaftor and a cystic fibrosis transmembrane regulatory protein (CFTR) modulator that corrects the folding and transport of CFTR proteins.Posenacaftor is used in studies related to cystic fibrosis (CF).

  Catalog
Abmole Inhibitor Catalog




Keywords: PG 01 supplier, CFTR, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.