FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.
| Molecular Weight | 486.49 |
| Formula | C27H23FN4O4 |
| CAS Number | 1628416-28-3 |
| Solubility (25°C) | DMSO 33 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Nicholas Gross. Chronic Obstr Pulm Dis. The COPD Pipeline XXXII
| Related CFTR Products |
|---|
| CFTR corrector 11
CFTR corrector 11 is a CFTR corrector. |
| CRF1 receptor antagonist-1
CRF1 receptor antagonist-1 is a CRF1 receptor antagonist. |
| CFTR corrector 12
CFTR corrector 12 is a bithiazole derivative, serving as CFTR corrector. |
| GLPG-3221
GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis. |
| Posenacaftor sodium
Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF). |
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