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FDL169

Cat. No. M20965
FDL169 Structure
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Biological Activity

FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.

Chemical Information
Molecular Weight 486.49
Formula C27H23FN4O4
CAS Number 1628416-28-3
Solubility (25°C) DMSO 33 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kevin W Southern, et al. Cochrane Database Syst Rev. Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants (most commonly F508del)

[2] Nicholas Gross. Chronic Obstr Pulm Dis. The COPD Pipeline XXXII

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