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FDL169

Cat. No. M20965

All AbMole products are for research use only, cannot be used for human consumption.

FDL169 Structure
Synonym:

CFTR corrector 2

Size Price Availability Quantity
1mg USD 30  USD30 In stock
5mg USD 75  USD75 In stock
10mg USD 115  USD115 In stock
25mg USD 190  USD190 In stock
50mg USD 340  USD340 In stock
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Quality Control & Documentation
Biological Activity

FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.

Chemical Information
Molecular Weight 486.49
Formula C27H23FN4O4
CAS Number 1628416-28-3
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kevin W Southern, et al. Cochrane Database Syst Rev. Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants (most commonly F508del)

[2] Nicholas Gross. Chronic Obstr Pulm Dis. The COPD Pipeline XXXII

Related CFTR Products
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NJH-2-057 

NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds ΔF508-CFTR.

GLPG2737

GLPG2737 is a novel potent Type 2 corrector of CFTR. GLPG2737 showed high permeability both in MDCKII-MDRI and Caco-2 cells, with low efflux allowing an elevated absorbed fraction FaxFg and a dose proportional increase in exposure in rat from a dose of 5 to 300 mg/kg, despite a low aqueous thermodynamic solubility.

UCCF-853

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(R)-Posenacaftor sodium

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  Catalog
Abmole Inhibitor Catalog




Keywords: FDL169, CFTR corrector 2 supplier, CFTR, inhibitors, activators

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