| Cat.No. | Name | Information |
|---|---|---|
| M2102 | VX-809 | VX-809 is a CFTR corrector that improves CFTR processing and maturation in the cell. |
| M54664 | (R)-Olacaftor | (R)-Olacaftor is a cystic fibrosis transmembrane regulator (CFTR) modulator that can be used in cystic fibrosis (CF) related studies. |
| M54662 | CFTR corrector 9 | CFTR corrector 9 is a cystic fibrosis transmembrane conductance regulator protein (CFTR) modulator for cystic fibrosis (CF) and other CFTR-related diseases. |
| M54661 | CFTR corrector 8 | CFTR corrector 8 is a potent modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and can be used in cystic fibrosis related studies. |
| M54660 | VRT-532 | VRT-532 is a potent modulator of cystic fibrosis transmembrane conductance regulator (CFTR) that enhances channel activity in G551D-CFTR and intrinsic ATPase activity in G551D-CFTR.VRT-532 can be used in cystic fibrosis related studies. |
| M54659 | (R)-Elexacaftor | (R)-Elexacaftor is an enantiomer of Elexacaftor and a corrector of cystic fibrosis transmembrane conductance regulator (CFTR) with an EC50 value of 0.29 μM for CFTR dF508. |
| M54658 | Ivacaftor hydrate | Ivacaftor hydrate is an orally active cystic fibrosis transmembrane conductance regulator (CFTR) enhancer for cystic fibrosis related studies. |
| M54654 | Crinecerfont hydrochloride | Crinecerfont hydrochloride is a potent, orally active, nonpeptide CRF1 receptor antagonist for use in congenital adrenal hyperplasia (CAH) studies. In addition, Crinecerfont hydrochloride is a click chemistry. It contains an Alkyne moiety that undergoes a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an Azide moiety. |
| M54653 | SRI-37240 | SRI-37240 is a potent inhibitor of premature termination codons (PTCs) that suppresses nonsense mutations in CFTR. In HEK293T cells, SRI-37240 alters the cellular translation termination of PTCs. When used in combination with G418, SRI-37240 also restores CFTR function in primary bronchial epithelial cells. |
| M54652 | Bamocaftor | Bamocaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector that restores F508del-CFTR protein function.Bamocaftor can be used in cystic fibrosis-related studies. |
| M54651 | Cavosonstat | Cavosonstat is an orally active nitrosoglutathione reductase (GSNOR) inhibitor. In addition, Cavosonstat is a CFTR stabilizer and can be used in cystic fibrosis studies. |
| M54649 | Navocaftor | Navocaftor is a cystic fibrosis transmembrane regulator (CFTR) modulator. |
| M54648 | SRI-41315 | SRI-41315 inhibits PTCs (premature termination codons) associated with cystic fibrosis in permanent and primary human bronchial epithelial cells by inducing a prolonged stoppage of the termination codon, restoring the expression and function of cystic fibrosis transmembrane conductance regulator (CFTR). In addition, SRI-41315 enhances aminoglycoside-mediated passaging, leading to a synergistic increase in CFTR activity. |
| M54647 | (R)-Vanzacaftor | (R)-Vanzacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). |
| M54645 | SION-109 | SION-109 is a transmembrane conductance regulator (CFTR) modulator that targets the interface of CFTR nucleotide-binding domain 1 (NBD1) interaction with the CFTR intracellular loop 4 (ICL4) protein domain. |
| M54644 | SION-719 | SION-719 is a potentially first-in-class transmembrane conductance regulator (CFTR) modulator that stabilizes nucleotide-binding domain 1 (NBD1) of CFTR protein. |
| M54643 | SION-451 | SION-451 is a potentially first-in-class transmembrane conductance regulator (CFTR) modulator that stabilizes nucleotide-binding domain 1 (NBD1) of CFTR protein. |
| M50209 | Deutivacaftor | Deutivacaftor is a potentiator that improves the flow of salt and water across cell membranes by increasing the probability of channel opening of CFTR proteins delivered to the cell surface.Deutivacaftor can be used in cystic fibrosis (CF) related studies. |
| M50208 | Vanzacaftor | Vanzacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector that increases the number of CFTR proteins on the cell surface by facilitating the processing and transport of CFTR proteins, and can be used in cystic fibrosis (CF) related studies. |
| M42173 | CFTR corrector 11 | CFTR corrector 11 is a CFTR corrector. |
| M42172 | CRF1 receptor antagonist-1 | CRF1 receptor antagonist-1 is a CRF1 receptor antagonist. |
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