| Cat.No. | Name | Information |
|---|---|---|
| M2102 | VX-809 | VX-809 is a CFTR corrector that improves CFTR processing and maturation in the cell. |
| M1854 | VX-770 (Ivacaftor) | VX-770 (Ivacaftor) is a first-in-class potentiator of CFTR, which targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. |
| M1771 | Ataluren | Ataluren (PTC124) is a novel, orally available small molecular CFTR-G542X nonsense allele inhibitor. |
| M56462 | GLPG2737 | GLPG2737 is a potent CFTR type 2 corrector, and GLPG2737 can be used in combination with a type 1 co-corrector in the study of cystic fibrosis. |
| M56461 | NJH-2-057 | NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds ΔF508-CFTR. |
| M54863 | GLPG2737 | GLPG2737 is a novel potent Type 2 corrector of CFTR. GLPG2737 showed high permeability both in MDCKII-MDRI and Caco-2 cells, with low efflux allowing an elevated absorbed fraction FaxFg and a dose proportional increase in exposure in rat from a dose of 5 to 300 mg/kg, despite a low aqueous thermodynamic solubility. |
| M54667 | UCCF-853 | UCCF-853 is a cystic fibrosis transmembrane regulatory protein (CFTR) modulator. |
| M54666 | (R)-Posenacaftor sodium | (R)-Posenacaftor sodium is the R-enantiomer of Posenacaftor and a cystic fibrosis transmembrane regulatory protein (CFTR) modulator that corrects the folding and transport of CFTR proteins.Posenacaftor is used in studies related to cystic fibrosis (CF). |
| M54664 | (R)-Olacaftor | (R)-Olacaftor is a cystic fibrosis transmembrane regulator (CFTR) modulator that can be used in cystic fibrosis (CF) related studies. |
| M54662 | CFTR corrector 9 | CFTR corrector 9 is a cystic fibrosis transmembrane conductance regulator protein (CFTR) modulator for cystic fibrosis (CF) and other CFTR-related diseases. |
| M54661 | CFTR corrector 8 | CFTR corrector 8 is a potent modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and can be used in cystic fibrosis related studies. |
| M54660 | VRT-532 | VRT-532 is a potent modulator of cystic fibrosis transmembrane conductance regulator (CFTR) that enhances channel activity in G551D-CFTR and intrinsic ATPase activity in G551D-CFTR.VRT-532 can be used in cystic fibrosis related studies. |
| M54659 | (R)-Elexacaftor | (R)-Elexacaftor is an enantiomer of Elexacaftor and a corrector of cystic fibrosis transmembrane conductance regulator (CFTR) with an EC50 value of 0.29 μM for CFTR dF508. |
| M54658 | Ivacaftor hydrate | Ivacaftor hydrate is an orally active cystic fibrosis transmembrane conductance regulator (CFTR) enhancer for cystic fibrosis related studies. |
| M54654 | Crinecerfont hydrochloride | Crinecerfont hydrochloride is a potent, orally active, nonpeptide CRF1 receptor antagonist for use in congenital adrenal hyperplasia (CAH) studies. In addition, Crinecerfont hydrochloride is a click chemistry. It contains an Alkyne moiety that undergoes a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an Azide moiety. |
| M54653 | SRI-37240 | SRI-37240 is a potent inhibitor of premature termination codons (PTCs) that suppresses nonsense mutations in CFTR. In HEK293T cells, SRI-37240 alters the cellular translation termination of PTCs. When used in combination with G418, SRI-37240 also restores CFTR function in primary bronchial epithelial cells. |
| M54652 | Bamocaftor | Bamocaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector that restores F508del-CFTR protein function.Bamocaftor can be used in cystic fibrosis-related studies. |
| M54651 | Cavosonstat | Cavosonstat is an orally active nitrosoglutathione reductase (GSNOR) inhibitor. In addition, Cavosonstat is a CFTR stabilizer and can be used in cystic fibrosis studies. |
| M54649 | Navocaftor | Navocaftor is a cystic fibrosis transmembrane regulator (CFTR) modulator. |
| M54647 | (R)-Vanzacaftor | (R)-Vanzacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). |
| M54645 | SION-109 | SION-109 is a transmembrane conductance regulator (CFTR) modulator that targets the interface of CFTR nucleotide-binding domain 1 (NBD1) interaction with the CFTR intracellular loop 4 (ICL4) protein domain. |
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