| Cat.No. | Name | Information |
|---|---|---|
| M2102 | VX-809 | VX-809 is a CFTR corrector that improves CFTR processing and maturation in the cell. |
| M54644 | SION-719 | SION-719 is a potentially first-in-class transmembrane conductance regulator (CFTR) modulator that stabilizes nucleotide-binding domain 1 (NBD1) of CFTR protein. |
| M54643 | SION-451 | SION-451 is a potentially first-in-class transmembrane conductance regulator (CFTR) modulator that stabilizes nucleotide-binding domain 1 (NBD1) of CFTR protein. |
| M50208 | Vanzacaftor | Vanzacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector that increases the number of CFTR proteins on the cell surface by facilitating the processing and transport of CFTR proteins, and can be used in cystic fibrosis (CF) related studies. |
| M42173 | CFTR corrector 11 | CFTR corrector 11 is a CFTR corrector. |
| M42172 | CRF1 receptor antagonist-1 | CRF1 receptor antagonist-1 is a CRF1 receptor antagonist. |
| M42171 | CFTR corrector 12 | CFTR corrector 12 is a bithiazole derivative, serving as CFTR corrector. |
| M29368 | GLPG-3221 | GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis. |
| M29208 | Posenacaftor sodium | Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF). |
| M29207 | Posenacaftor | Posenacaftor (PTI-801) is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF). |
| M29021 | Galicaftor | Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. Galicaftor can be used for cystic fibrosis research. |
| M29020 | CFTR corrector 4 | CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis. |
| M29003 | Olacaftor | Olacaftor (VX-440) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408. |
| M28368 | (R)-BPO-27 | (R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR inhibitor with an IC50 of 4 nM. |
| M21215 | CP-628006 | CP-628006 is a CFTR small molecule enhancer that enhances CFTR function in human bronchial epithelial (hBE) cells and restores ATP-dependent gated channels in cystic fibrosis mutant G551D-CFTR. It can be used in cystic fibrosis (CF) related studies. |
| M21132 | NJH-2-057 | NJH-2-057 is a conjugate of the deubiquitinase OTUB1 covalent ligand-linked lumacaftor, which stabilizes mutant CFTR proteins in cells. |
| M21104 | GLPG2451 | GLPG2451 is an enhancer of cystic fibrosis transmembrane conductance regulator (CFTR) and effectively enhances cryo-rescued F508del CFTR with an EC50 of 11.1 nM. |
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