| Cat.No. | Name | Information |
|---|---|---|
| M2102 | VX-809 | VX-809 is a CFTR corrector that improves CFTR processing and maturation in the cell. |
| M42171 | CFTR corrector 12 | CFTR corrector 12 is a bithiazole derivative, serving as CFTR corrector. |
| M29368 | GLPG-3221 | GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis. |
| M29208 | Posenacaftor sodium | Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF). |
| M29207 | Posenacaftor | Posenacaftor (PTI-801) is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF). |
| M29021 | Galicaftor | Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. Galicaftor can be used for cystic fibrosis research. |
| M29020 | CFTR corrector 4 | CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis. |
| M29003 | Olacaftor | Olacaftor (VX-440) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408. |
| M28368 | (R)-BPO-27 | (R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR inhibitor with an IC50 of 4 nM. |
| M21215 | CP-628006 | CP-628006 is a CFTR small molecule enhancer that enhances CFTR function in human bronchial epithelial (hBE) cells and restores ATP-dependent gated channels in cystic fibrosis mutant G551D-CFTR. It can be used in cystic fibrosis (CF) related studies. |
| M21132 | NJH-2-057 | NJH-2-057 is a conjugate of the deubiquitinase OTUB1 covalent ligand-linked lumacaftor, which stabilizes mutant CFTR proteins in cells. |
| M21104 | GLPG2451 | GLPG2451 is an enhancer of cystic fibrosis transmembrane conductance regulator (CFTR) and effectively enhances cryo-rescued F508del CFTR with an EC50 of 11.1 nM. |
| M20965 | FDL169 | FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein. |
| M14206 | Nesolicaftor | Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier. |
| M14205 | BPO-27 racemate | BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM. |
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