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CP-628006

Cat. No. M21215
CP-628006  Structure
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Biological Activity

CP-628006 is a CFTR small molecule enhancer that enhances CFTR function in human bronchial epithelial (hBE) cells and restores ATP-dependent gated channels in cystic fibrosis mutant G551D-CFTR. It can be used in cystic fibrosis (CF) related studies.

Chemical Information
Molecular Weight 536.63
Formula C32H35F3N2O2
CAS Number 305822-08-6
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jia Liu, et al. Br J Pharmacol. A small molecule CFTR potentiator restores ATP-dependent channel gating to the cystic fibrosis mutant G551D-CFTR

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