Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF).
Molecular Weight | 467.49 |
Formula | C27H26NNaO5 |
CAS Number | 2095064-06-3 |
Form | Solid |
Solubility (25°C) | DMSO 200 mg/mL (ultrasonic) |
Storage | 4°C, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Megan C Romano, et al. J Vet Diagn Invest. Sodium distribution in the bovine brain
[2] Frank G Zöllner, et al. NMR Biomed. Quantitative sodium MRI of kidney
[3] Jens Titze, et al. Kidney Int. Spooky sodium balance
[4] Gregor Lindner, et al. J Crit Care. Hypernatremia in critically ill patients
Related CFTR Products |
---|
CFTR corrector 11
CFTR corrector 11 is a CFTR corrector. |
CRF1 receptor antagonist-1
CRF1 receptor antagonist-1 is a CRF1 receptor antagonist. |
CFTR corrector 12
CFTR corrector 12 is a bithiazole derivative, serving as CFTR corrector. |
GLPG-3221
GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis. |
Posenacaftor
Posenacaftor (PTI-801) is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF). |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.