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Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF).
| Molecular Weight | 467.49 |
| Formula | C27H26NNaO5 |
| CAS Number | 2095064-06-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 200 mg/mL (ultrasonic) |
| Storage | 4°C, dry, sealed |
[1] Megan C Romano, et al. J Vet Diagn Invest. Sodium distribution in the bovine brain
[2] Frank G Zöllner, et al. NMR Biomed. Quantitative sodium MRI of kidney
[3] Jens Titze, et al. Kidney Int. Spooky sodium balance
[4] Gregor Lindner, et al. J Crit Care. Hypernatremia in critically ill patients
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GLPG2737 is a potent CFTR type 2 corrector, and GLPG2737 can be used in combination with a type 1 co-corrector in the study of cystic fibrosis. |
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NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds ΔF508-CFTR. |
| GLPG2737
GLPG2737 is a novel potent Type 2 corrector of CFTR. GLPG2737 showed high permeability both in MDCKII-MDRI and Caco-2 cells, with low efflux allowing an elevated absorbed fraction FaxFg and a dose proportional increase in exposure in rat from a dose of 5 to 300 mg/kg, despite a low aqueous thermodynamic solubility. |
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| (R)-Posenacaftor sodium
(R)-Posenacaftor sodium is the R-enantiomer of Posenacaftor and a cystic fibrosis transmembrane regulatory protein (CFTR) modulator that corrects the folding and transport of CFTR proteins.Posenacaftor is used in studies related to cystic fibrosis (CF). |
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