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CFTR corrector 4 

Cat. No. M29020

All AbMole products are for research use only, cannot be used for human consumption.

CFTR corrector 4  Structure

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Biological Activity

CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis.

Chemical Information
Molecular Weight 539.52
Formula C29H27F2NO7
CAS Number 1918142-34-3
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] John A King, et al. Paediatr Drugs. An Update on CFTR Modulators as New Therapies for Cystic Fibrosis

[2] Kevin W Southern, et al. Cochrane Database Syst Rev. Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants (most commonly F508del)

[3] Peter G Middleton, et al. N Engl J Med. Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele

[4] Harry G M Heijerman, et al. Lancet. Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial

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Keywords: CFTR corrector 4  supplier, CFTR, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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