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PPQ-102

Cat. No. M3147

All AbMole products are for research use only, cannot be used for human consumption.

PPQ-102 Structure
Synonym:

CFTR Inhibitor

Size Price Availability Quantity
10mM*1mL in DMSO USD 100  USD100 In stock
5mg USD 90  USD90 In stock
10mg USD 155  USD155 In stock
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Quality Control & Documentation
Biological Activity

PPQ-102 inhibites CFTR chloride current with IC 50 approximately 90 nM. PPQs are uncharged at physiological pH, so not subject to membrane potential-dependent cellular partitioning or block efficiency. PPQ-102 prevents cyst expansion and reduces the size of preformed cysts in a neonatal kidney organ culture model of polycystic kidney disease. PPQ-102 is the most potent CFTR inhibitor identified to date.

Chemical Information
Molecular Weight 438.48
Formula C26H22N4O3
CAS Number 931706-15-9
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Tradtrantip L, et al. J Med Chem. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model.

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Keywords: PPQ-102, CFTR Inhibitor supplier, CFTR, inhibitors, activators

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