R1881, also known as methyltrienolone, is a synthetic androgen being a 17α-alkylated nandrolone (19-nortestosterone) derivative. R1881 (Metribolone) binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors. R1881 (Metribolone) is the gold standard AR agonist. Androgen receptors (ARs) are nuclear hormone receptors/transcription factors.
Cancers (Basel). 2023 Apr 27;15(9):2517.
Cannabidiol as a Promising Adjuvant Therapy for Estrogen Receptor-Positive Breast Tumors: Unveiling Its Benefits with Aromatase Inhibitors
R1881 purchased from AbMole
Molecules. 2023 Jan 12;28(2):789.
An Exemestane Derivative, Oxymestane-D1, as a New Multi-Target Steroidal Aromatase Inhibitor for Estrogen Receptor-Positive (ER+) Breast Cancer: Effects on Sensitive and Resistant Cell Lines
R1881 purchased from AbMole
Front Endocrinol (Lausanne). 2022 May 31;13:862789.
TMPRSS2 Expression and Activity Modulation by Sex-Related Hormones in Lung Calu-3 Cells: Impact on Gender-Specific SARS-CoV-2 Infection
R1881 purchased from AbMole
| Molecular Weight | 284.39 |
| Formula | C19H24O2 |
| CAS Number | 965-93-5 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] L F Fanjul, et al. R1881 regulation of steroidogenesis in cultured testicular cells
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| Androstenone
Androstenone is a steroid pheromone and also a metabolite of androgens. |
| (Des-Glu5)-ACTH (1-24) (human, bovine, rat)
(Des-Glu5)-ACTH (1-24) (human, bovine, rat) is an analogue of Adrenocorticotropic hormone (ACTH). |
| Acetyl-ACTH (2-24) (human, bovine, rat)
Acetyl-ACTH (2-24) (human, bovine, rat) is a fragment of proopiomelanocortin (POMC) peptide. |
| Acetyl-ACTH (3-24) (human, bovine, rat)
Acetyl-ACTH (3-24) (human, bovine, rat) is a fragment of proopiomelanocortin (POMC) peptide. |
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