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Cat. No. M9164
Insulin(cattle) Structure
Size Price Availability Quantity
10mg USD 75  USD75 In stock
25mg USD 137  USD137 In stock
50mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Insulin is a peptide hormone produced by beta cells of the pancreatic islets.

*This compound is unstable in the solution state, so it is recommended to use it now and use it as soon as possible.

Insulin has low solubility at neutral pH. It can be solubilized at 2 mg/ml in dilute acetic or hydrochloric acid, pH 2-3.

A stock solution can be stored frozen at -20°C in single-use aliquots. Freeze-thaw cycles should be avoided. Alternatively, it can be stored for up to 12 months at 2-8°C if it is sterile filtered through a low protein binding membrane or if it contains a suitable bacteriostat, such as 0.1% thimerosal or sodium azide.

Insulin solutions cannot be autoclaved.

Insulin can also be solubilized in 125 mM NaHCO3.6 However, alkaline stock solutions are not recommended since high pH increases the rate of deamidation and aggregation.

1. Do not prepare concentrated insulin solutions, as solubility is difficult and multimers can form.
2. Adjust to acidic pH to facilitate solubilization and minimize the effects of neutral pH-binding proteases. For added protection, consider adding an acid protease inhibitor.
3. Sterile-filter the solution using a 0.2 micron low protein-binding filter. Avoid aeration and/or foaming during solubilization and filtration, as this can cause protein denaturation.
4. Store solutions at 2-8 °C for up to 8 hours.
5. Do not heat above 30 °C and do not freeze.
6. The recommended insulin working concentration is 1-10 μg/mL.
As an alternative, Insulin solutions can be prepared with phosphate buffered solution (PBS). Resolubilize the aforementioned products in PBS at a concentration of 1 mg/mL. Allow to gently rock for at least 1-2 hours at room temperature. Do not vortex. Solution is ready when clear. Prior to evaluation, follow steps 3–6 for final processing.

Product Citations
Chemical Information
Molecular Weight 5733.49
Formula C254H377N65O75S6
CAS Number 11070-73-8
Solubility (25°C) Water 10 mg/mL (adjust pH to 2~3 with HCl)
Storage -20°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Yousefi R, et al. J Biomol Struct Dyn. Aspirin-mediated acetylation induces structural alteration and aggregation of bovine pancreatic insulin.

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