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Nigericin sodium salt

Cat. No. M7029
Nigericin sodium salt Structure
Synonym:

Sodium Nigericin

Size Price Availability Quantity
5mg USD 85  USD85 In stock
10mg USD 145  USD145 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Nigericin sodium salt is a potassium ionophore, exchanges K+ for H+ across biological membranes, in a similar manner to Valinomycin. Stimulates mitochondral ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius. Nigericin sodium salt is also an NLRP3 activator which can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 746.94
Formula C40H67NaO11
CAS Number 28643-80-3
Purity >98%
Solubility Ethanol ≥ 30 mg/mL
Storage 2-8°C, dry, protect from light, sealed
References

[1] Sebastian Vogel, et al. Biochem Biophys Res Commun. TLR4-dependent upregulation of the platelet NLRP3 inflammasome promotes platelet aggregation in a murine model of hindlimb ischemia

[2] Jun Ren, et al. Biochim Biophys Acta Mol Basis Dis. Inhibition of CYP2E1 attenuates myocardial dysfunction in a murine model of insulin resistance through NLRP3-mediated regulation of mitophagy

[3] A Saeki, et al. Mol Oral Microbiol. Activation of NLRP3 inflammasome in macrophages by mycoplasmal lipoproteins and lipopeptides

[4] Paul J Baker, et al. Eur J Immunol. NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

[5] Pulvino, et al. Blood. Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A.

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Keywords: Nigericin sodium salt, Sodium Nigericin supplier, Potassium Channel, inhibitors

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