| Cat.No. | Name | Information |
|---|---|---|
| M7029 | Nigericin sodium salt | Nigericin (NSC 292567) sodium salt is a selective K+ ionophore, Nigericin sodium salt is also an NLRP3 activator which can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes. |
| M4973 | BAPTA-AM | BAPTA-AM is a selective, membrane-permeable calcium chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively. |
| M3456 | Chlorpromazine hydrochloride | Chlorpromazine hydrochloride is an antagonist of D2, 5HT2A, potassium and sodium channels. The Ki of Chlorpromazine Hydrochloride to D2 and 5HT2A were 363 nM and 8.3 nM, respectively. Chlorpromazine also excites the 20S proteasome. *The compound is unstable in solutions, freshly prepared is recommended |
| M2181 | ML133 hydrochloride | ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. |
| M55441 | Retigabine-d4 | Retigabine-d4 |
| M53944 | Apamin | Apamin (Apamine) is a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity. |
| M52734 | Phrixotoxin-1 | Phrixotoxin 1, from the venom of the theraphosid spider Phrixotrichus auratus, is a specific peptide inhibitor of Kv4 potassium channel. |
| M31356 | Iberiotoxin TFA | Iberiotoxin TFA is also a selective, high-affinity blocker of the large conductance calcium-activated potassium channel (BKCa) with a Kd of approximately 1 nM. |
| M30635 | Quinine hemisulfate | Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM. |
| M22444 | Flupirtine | Flupirtine |
| M21491 | Rimtuzalcap | Rimtuzalcap (CAD-1883) is the first (first-in-class), selective small conductance calcium-activated potassium channel (SK channel) positive allosteric regulator. Rimtuzalcap can be used in the study of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA). |
| M20428 | Retigabine 2HCl | Retigabine is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels. |
| M14263 | Tertiapin-Q | Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir1.1). |
| M14262 | Tannic acid | Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM. |
| M14261 | Senicapoc | Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM. |
| M14258 | PAP-1 | PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC50=2 nM). |
| M14257 | N-Acetylprocainamide | N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels. |
| M14253 | GAL-021 | GAL-021 is a potent BKCa-channel blocker. |
| M13339 | L-Palmitoylcarnitine | L-palmitoyl carnitine is a long-chain acylcarnitine and fatty acid metabolite that accumulates in the sarcoid during ischemia and disrupts the membrane lipid environment. L-palmitoylcarnitine inhibits KATP channel activity by interacting with Kir6.2 without affecting single channel conductance. |
| M10624 | Tetraethylammonium chloride | Tetraethylammonium chloride is a non-selective potassium channel blocker with antitumor properties. |
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