| Cat.No. | Name | Information |
|---|---|---|
| M4973 | BAPTA-AM | BAPTA-AM is a selective, membrane-permeable calcium chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively. |
| M2181 | ML133 hydrochloride | ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. |
| M3456 | Chlorpromazine hydrochloride | Chlorpromazine hydrochloride is an antagonist of D2, 5HT2A, potassium and sodium channels. The Ki of Chlorpromazine Hydrochloride to D2 and 5HT2A were 363 nM and 8.3 nM, respectively. Chlorpromazine also excites the 20S proteasome. *The compound is unstable in solutions, freshly prepared is recommended |
| M7029 | Nigericin sodium salt | Nigericin (NSC 292567) sodium salt is a selective K+ ionophore, Nigericin sodium salt is also an NLRP3 activator which can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes. |
| M20428 | Retigabine 2HCl | Retigabine is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels. |
| M9780 | Nigericin | Nigericin is an antibiotic derived from Streptomyces hygroscopicus, it acts as an H+, K+, Pb2+ ionophore. |
| M4891 | Ns6180 | NS6180 is a highly selective inhibitor of KCa3.1 ion channels with an IC50 value of 9nM, blocking T cell activation and inflammatory response. |
| M4584 | Acacetin | Acacetin is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects. |
| M4332 | Paederosidic-acid-methyl-ester | Paederosidic acid Methyl ester, an ATP-sensitive K+ Channel activator, was isolated from P. scandens. Paederosidic acid Methyl ester has shown significant central pain-relieving activity, increasing pain thresholds by activating ATP-sensitive K+ channels in the brain and spinal cord levels. |
| M4160 | Soyasaponin-Be | Dehydrosoyasaponin I (Soyasaponin Be; Dhs-i, a triterpenoid glycoside, is a potent and reversible calcium-activated potassium (MAxi-K) channel activator. |
| M4031 | Talatisamine | Talatisamine isa kind of aconite alkaloid, which isa specific K+ channel blocker. Talatisamine attenuated the neurotoxicity of beta-amyloid oligomers to cultured cortical neurons. |
| M3957 | Mitiglinide calcium | Mitiglinide (KAD 1229, S 21403), a derivative of benzysuccinic acid, is a potassium channel antagonist developed with Kissei for the study of type 2 diabetes. |
| M3718 | Dronedarone hydrochloride | Donedarone hydrochloride is a new compound with a similar structure to amiodarone and has better side effects. |
| M3714 | Repaglinide | Repaglinide is an insulin secretagogue used in type 2 diabetes. |
| M3622 | Vernakalant | Vernakalant (RSD-1235) is an investigational mixed ion channel blocker, which can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents. |
| M3505 | Glipizide | Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. |
| M3464 | Indapamide | Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure. |
| M3452 | Quinine hydrochloride Dihydrate | Quinine hydrochloride Dihydrate is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste. |
| M3449 | PF-3716556 | PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+ |
| M3415 | Nateglinide | Nateglinide is an orally active, short-acting insulin-releasing compound that is also an inhibitor of DPP IV. Nateglinide inhibits ATP-sensitive K+ channels in islet β cells. Nateglinide is available for the study of type 2 diabetes mellitus (non-insulin-dependent). |
| M3399 | Gliclazide | Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. |
| M3343 | Nicorandil | Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). |
| M3192 | TRAM-34 | TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450. |
| M3077 | Tolbutamide | Tolbutamide is an inhibitor of cAMP with IC50 of 4 mM, it is also an inhibitor of potassium channel, used for type II diabetes. |
| M3058 | Terfenadine | Terfenadine is an antihistamine compound that is normally fully metabolized in the liver by the cytochrome P450 CYP3A4 subtype enzyme into the active form fexofenadine. |
| M2946 | Pinacidil monohydrate | Pinacidil monohydrate is known to augment a time-independent outward current in cardiac tissues by activating the ATP-regulated potassium channels. |
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