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Nateglinide

Cat. No. M3415
Nateglinide Structure
Synonym:

A-4166

Size Price Availability Quantity
10mg USD 50  USD50 In stock
25mg USD 95  USD95 In stock
50mg USD 165  USD165 In stock
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Quality Control & Documentation
Biological Activity

Nateglinide is an orally active, short-acting insulin-releasing compound that is also an inhibitor of DPP IV. Nateglinide inhibits ATP-sensitive K+ channels in islet β cells. Nateglinide is available for the study of type 2 diabetes mellitus (non-insulin-dependent).

Chemical Information
Molecular Weight 317.42
Formula C19H27NO3
CAS Number 105816-04-4
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Med Lett Drugs Ther. Drugs for type 2 diabetes

[2] No authors listed. Nateglinide

[3] No authors listed. Nateglinide

[4] C J Halas. Nateglinide

[5] C J Dunn, et al. Nateglinide

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Keywords: Nateglinide, A-4166 supplier, Potassium Channel, inhibitors, activators


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