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Nigericin

Cat. No. M9780
Nigericin Structure
Synonym:

Antibiotic K178, Antibiotic X464

Size Price Availability
5mg USD 120  USD120 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Nigericin is an antibiotic derived from Streptomyces hygroscopicus, it acts as an H+, K+, Pb2+ ionophore. Nigericin was used as an antibiotic active against gram positive bacteria. It inhibits the Golgi functions in Eukaryotic cells. Nigericin exhibits anticancer and anti-HIV activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 724.9
Formula C40H68O11
CAS Number 28380-24-7
Purity >98%
Solubility DMSO
Storage 2-8°C, dry, protect from light, sealed
References

[1] Soner Bilen, et al. Dev Comp Immunol. Inflammatory responses in the Japanese pufferfish (Takifugu rubripes) head kidney cells stimulated with an inflammasome-inducing agent, nigericin

[2] Cheng-Cheng Deng, et al. Int J Biochem Cell Biol. Nigericin selectively targets cancer stem cells in nasopharyngeal carcinoma

[3] Gregory R Sturz, et al. Chem Senses. The K+-H+ exchanger, nigericin, modulates taste cell pH and chorda tympani taste nerve responses to acidic stimuli

[4] Chad Myskiw, et al. Antiviral Res. Nigericin is a potent inhibitor of the early stage of vaccinia virus replication

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Keywords: Nigericin, Antibiotic K178, Antibiotic X464 supplier, Potassium Channel, inhibitors

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