| Cat.No. | Name | Information |
|---|---|---|
| M4973 | BAPTA-AM | BAPTA-AM is a selective, membrane-permeable calcium chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively. |
| M2181 | ML133 hydrochloride | ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. |
| M3456 | Chlorpromazine hydrochloride | Chlorpromazine hydrochloride is an antagonist of D2, 5HT2A, potassium and sodium channels. The Ki of Chlorpromazine Hydrochloride to D2 and 5HT2A were 363 nM and 8.3 nM, respectively. Chlorpromazine also excites the 20S proteasome. *The compound is unstable in solutions, freshly prepared is recommended |
| M7029 | Nigericin sodium salt | Nigericin (NSC 292567) sodium salt is a selective K+ ionophore, Nigericin sodium salt is also an NLRP3 activator which can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes. |
| M20428 | Retigabine 2HCl | Retigabine is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels. |
| M9780 | Nigericin | Nigericin is an antibiotic derived from Streptomyces hygroscopicus, it acts as an H+, K+, Pb2+ ionophore. |
| M7177 | Quinine hydrochloride | Quinine hydrochloride is the hydrochloride form of Quinine, an alkaloid extracted from the bark of the cinchona tree, with antimalarial and antitumor activities, and an IC50 value of 60 ng/mL against P. falciparum strains passou and 107.8 ng/mL against P. falciparum strain 3CD7, respectively, and an inhibitor of potassium channels. Quinine hydrochloride is also a potassium channel inhibitor that inhibits voltage pulse-induced MT mSlo3 (KCa5.1) channel +100 mV currents, with an IC50 value of 169 μM. In addition, Quinine hydrochloride binds to purine nucleoside phosphorylase (PfNP) and PfNP with low nanomolar affinity. nucleoside phosphorylase (PfPNP) with low nanomolar affinity. |
| M7103 | Paxilline | Paxilline is a sERCA ATPase blocker. Also potent BKCa channel blocker. |
| M7052 | NS 5806 | NS 5806 is a k V4.3 channel activator. |
| M7049 | NS309 | NS309 is a positive modulator of KCa2 and KCa3.1 channels. NS309 displays no activity at BK channels. |
| M6981 | ML 365 | ML 365 is a potent and selective K2P3.1 TASK-1 channel blocker. |
| M6975 | ML297 | ML297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator. |
| M6906 | Levcromakalim | Levcromakalim is a k ir6 (K ATP) channel opener; active enantiomer of cromakalim. |
| M6735 | Flupirtine maleate | Flupirtine maleate is a selective potassium channel opener, NMDA receptor antagonist and GABAA receptor modulator. |
| M6625 | CP 339818 hydrochloride | CP 339818 hydrochloride is a non-peptide, potent KV1.3 channel blocker. CP 339818 hydrochloride potently blocks the C-type inactivated conformation of Kv1.3 and suppresses T cell activation. |
| M6580 | Cesium chloride | Cesium chloride is a potassium channel blocker; neuroprotective. |
| M6323 | 1-EBIO | 1-EBIO is a activator of epithelial K Ca channels. |
| M6161 | GSK369796 Dihydrochloride | GSK369796 shows antimalerial activity with IC50 values of 11.2 nM for 3D7 strain, 12.6 nM for HB3 strain, 17.6 nM for K1 strain. |
| M6052 | Vernakalant HCl | Vernakalant Hcl(RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic. |
| M5569 | Diazoxide | Diazoxide is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions. |
| M5437 | Azimilide | Azimilide(NE-10064) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes. |
| M5409 | Amiodarone hydrochloride | Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias. |
| M5406 | Amifampridine | Amifampridine is a drug, predominantly in the treatment of a number of rare muscle diseases. |
| M5302 | ICA069673 | ICA-069673 is a KCNQ2/Q3 potassium channel activator with an IC50 of 0.69 μM. |
| M5072 | NS-1619 | NS-1619 is a selective large conductance Ca2+-activated K+-channel activator. NS-1619 is a highly effective relaxant with an EC50 of about 10-30 μM in several smooth muscles of blood vessels and other tissues. |
| M4968 | Mitiglinide calcium hydrate | Miglinide calcium hydrate is a compound used to study type 2 diabetes mellitus. It is a highly selective KATP channel antagonist. |
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