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Diazoxide

Cat. No. M5569
Diazoxide Structure
Synonym:

Sch-6783, SRG-95213, Proglycem

Size Price Availability Quantity
100mg USD 80  USD80 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Diazoxide is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 230.67
Formula C8H7ClN2O2S
CAS Number 364-98-7
Purity >98%
Solubility 46 mg/mL in DMSO
Storage at -20°C
References

[1] Virgili N, et al. J Neuroimmune Pharmacol. Diazoxide attenuates autoimmune encephalomyelitis and modulates lymphocyte proliferation and dendritic cell functionality.

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Keywords: Diazoxide, Sch-6783, SRG-95213, Proglycem supplier, Potassium Channel, inhibitors

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