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Minoxidil

Cat. No. M7926
Minoxidil Structure
Synonym:

U10858

Size Price Availability Quantity
1g USD 55  USD55 In stock
2g USD 87  USD87 In stock
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Quality Control
Biological Activity

Minoxidil activates ATP-activated K+ channels; vasodilator; slow or stop hair loss and promote hair regrowth.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 209.25
Formula C9H15N5O
CAS Number 38304-91-5
Purity >98%
Solubility DMSO 3 mg/mL warmed
Storage at -20°C
References

[1] Michael Randolph, et al. Oral minoxidil treatment for hair loss: A review of efficacy and safety

[2] Poonkiat Suchonwanit, et al. Minoxidil and its use in hair disorders: a review

[3] Jenna R Stoehr, et al. Off-Label Use of Topical Minoxidil in Alopecia: A Review

[4] Andy Goren, et al. Minoxidil in the treatment of androgenetic alopecia

[5] Aditya K Gupta, et al. 5% Minoxidil: treatment for female pattern hair loss

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