Minoxidil activates ATP-activated K+ channels; vasodilator; slow or stop hair loss and promote hair regrowth.
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Molecular Weight | 209.25 |
Formula | C9H15N5O |
CAS Number | 38304-91-5 |
Purity | >98% |
Solubility | DMSO 3 mg/mL warmed |
Storage | at -20°C |
[1] Michael Randolph, et al. Oral minoxidil treatment for hair loss: A review of efficacy and safety
[2] Poonkiat Suchonwanit, et al. Minoxidil and its use in hair disorders: a review
[3] Jenna R Stoehr, et al. Off-Label Use of Topical Minoxidil in Alopecia: A Review
[4] Andy Goren, et al. Minoxidil in the treatment of androgenetic alopecia
[5] Aditya K Gupta, et al. 5% Minoxidil: treatment for female pattern hair loss
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