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Vernakalant HCl

Cat. No. M6052
Vernakalant HCl Structure
Synonym:

RSD1235 hydrochloride

Size Price Availability Quantity
10mg USD 380  USD380 In stock
50mg USD 1050  USD1050 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Vernakalant Hcl(RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 385.93
Formula C20H32ClNO4
CAS Number 748810-28-8
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

[1] Savelieva I, et al. Europace. Pharmacological cardioversion of atrial fibrillation with vernakalant: evidence in support of the ESC Guidelines.

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Keywords: Vernakalant HCl, RSD1235 hydrochloride supplier, Potassium Channel, inhibitors

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