| Cat.No. | Name | Information |
|---|---|---|
| M4973 | BAPTA-AM | BAPTA-AM is a selective, membrane-permeable calcium chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively. |
| M2181 | ML133 hydrochloride | ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. |
| M3456 | Chlorpromazine hydrochloride | Chlorpromazine hydrochloride is an antagonist of D2, 5HT2A, potassium and sodium channels. The Ki of Chlorpromazine Hydrochloride to D2 and 5HT2A were 363 nM and 8.3 nM, respectively. Chlorpromazine also excites the 20S proteasome. *The compound is unstable in solutions, freshly prepared is recommended |
| M7029 | Nigericin sodium salt | Nigericin (NSC 292567) sodium salt is a selective K+ ionophore, Nigericin sodium salt is also an NLRP3 activator which can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes. |
| M20428 | Retigabine 2HCl | Retigabine is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels. |
| M9780 | Nigericin | Nigericin is an antibiotic derived from Streptomyces hygroscopicus, it acts as an H+, K+, Pb2+ ionophore. |
| M20808 | ML277 | ML277 (CID-53347902) is a potent activator of KCNQ1 channels with an EC50 of 260 nM and shows >100-fold selectivity over KCNQ2 and KCNQ4. |
| M14263 | Tertiapin-Q | Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir1.1). |
| M14262 | Tannic acid | Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM. |
| M14261 | Senicapoc | Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM. |
| M14258 | PAP-1 | PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC50=2 nM). |
| M14257 | N-Acetylprocainamide | N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels. |
| M14253 | GAL-021 | GAL-021 is a potent BKCa-channel blocker. |
| M13339 | L-Palmitoylcarnitine | L-palmitoyl carnitine is a long-chain acylcarnitine and fatty acid metabolite that accumulates in the sarcoid during ischemia and disrupts the membrane lipid environment. L-palmitoylcarnitine inhibits KATP channel activity by interacting with Kir6.2 without affecting single channel conductance. |
| M10624 | Tetraethylammonium chloride | Tetraethylammonium chloride is a non-selective potassium channel blocker with antitumor properties. |
| M10575 | Charybdotoxin TFA | Charybdotoxin TFA, a 37-amino acid peptide, is a K+ channel blocker. |
| M10516 | AUT1 | AUT1 is a Kv3 potassium channel modulator which increases whole currents mediated by human Kv3.1b and Kv3.2a channels, with a concomitant leftward shift in the voltage-dependence of activation, while having a less potent effect on hKv3.3 currents. |
| M9820 | 2,2,2-Trichloroethanol | 2,2,2-Trichloroethanol is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4). |
| M9700 | ML213 | ML213 (CID-3111211) is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener, with EC50 values of 230 and 510 nM for KV7.2 and KV7.4, respectively. |
| M9423 | CLP290 | CLP290 is a novel, orally available KCC2 modulator, highly selective for KCC2 over related Cl- transporters. |
| M9394 | BMS-191011 | BMS-191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). |
| M8906 | Sematilide hydrochloride | Sematilide (CK-1752) hydrochloride is a novel class III antiarrhythmic agent. |
| M8837 | UK-78282 monohydrochloride | UK-78282 is a novel, potent and selective Kv1.3 blocker with an IC50 of 200 nM. UK-78282 effectively suppresses human T-lymphocyte activation in vitro. UK-78282 binds to residues at the inner surface of the channel overlapping the site of action of verapamil. |
| M8698 | Kurarinone | Kurarinone, a flavanone from Sophora flavescens roots, is a potent activator of the large-conductance calcium-activated potassium channel (BKCa channel). |
| M8223 | VU591 | VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) that is closely related to VU590. |
| M7926 | Minoxidil | Minoxidil activates ATP-activated K+ channels; vasodilator; slow or stop hair loss and promote hair regrowth. |
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