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Potassium Channel Potassium channel

Inhibitors

Cat.No.  Name Information
M5302 ICA069673 ICA-069673 is a KCNQ2/Q3 potassium channel activator with an IC50 of 0.69 μM.
M4584 Acacetin Acacetin is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects.
M4332 Paederosidic-acid-methyl-ester Paederosidic acid Methyl ester, an ATP-sensitive K+ Channel activator, was isolated from P. scandens. Paederosidic acid Methyl ester has shown significant central pain-relieving activity, increasing pain thresholds by activating ATP-sensitive K+ channels in the brain and spinal cord levels.
M4160 Soyasaponin-Be Dehydrosoyasaponin I (Soyasaponin Be; Dhs-i, a triterpenoid glycoside, is a potent and reversible calcium-activated potassium (MAxi-K) channel activator.
M4031 Talatisamine Talatisamine isa kind of aconite alkaloid, which isa specific K+ channel blocker. Talatisamine attenuated the neurotoxicity of beta-amyloid oligomers to cultured cortical neurons.
M3714 Repaglinide Repaglinide is an insulin secretagogue used in type 2 diabetes.
M3622 Vernakalant Vernakalant (RSD-1235) is an investigational mixed ion channel blocker, which can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents.
M3464 Indapamide Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.
M3456 Chlorpromazine hydrochloride Chlorpromazine hydrochloride is an antagonist of D2, 5HT2A, potassium and sodium channels. The Ki of Chlorpromazine Hydrochloride to D2 and 5HT2A were 363 nM and 8.3 nM, respectively. Chlorpromazine also excites the 20S proteasome. *The compound is unstable in solutions, freshly prepared is recommended
M3415 Nateglinide Nateglinide is an orally active, short-acting insulin-releasing compound that is also an inhibitor of DPP IV. Nateglinide inhibits ATP-sensitive K+ channels in islet β cells. Nateglinide is available for the study of type 2 diabetes mellitus (non-insulin-dependent).
M3399 Gliclazide Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.
M3343 Nicorandil Nicorandil is potassium channel activator.
M3192 TRAM-34 TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450.
M3077 Tolbutamide Tolbutamide is an inhibitor of cAMP with IC50 of 4 mM, it is also an inhibitor of potassium channel, used for type II diabetes.
M2724 Gliquidone Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.
M2181 ML133 hydrochloride ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels.
M2043 TAK-438 TAK-438 is a novel and potent potassium-competitive acid blocker (P-CAB) with IC50 of 19 nM.
M1797 Retigabine Retigabine is a KCNQ/Kv7 potassium channel activator which functions by enhancing potassium currents via stabilizing the open conformation of the Kv7.2-7.3 channels.



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