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AUT1

Cat. No. M10516
AUT1 Structure
Synonym:

AUT-1

Size Price Availability Quantity
5mg USD 440  USD440 In stock
10mg USD 730  USD730 In stock
50mg USD 2180  USD2180 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

AUT1 is a Kv3 potassium channel modulator which increases whole currents mediated by human Kv3.1b and Kv3.2a channels, with a concomitant leftward shift in the voltage-dependence of activation, while having a less potent effect on hKv3.3 currents. AUT1 has pEC50 values of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively, exhibits 10-fold lower potency at human recombinant Kv3.3 channel (pEC50, 4.5).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 341.36
Formula C18H19N3O4
CAS Number 1311136-84-1
Purity >99%
Solubility DMSO ≥ 100 mg/mL
Storage at -20°C
References

[1] Timothy Olsen, et al. Neuropharmacology. Kv3 K+ currents contribute to spike-timing in dorsal cochlear nucleus principal cells

[2] Puja K Parekh, et al. Neuropsychopharmacology. Antimanic Efficacy of a Novel Kv3 Potassium Channel Modulator

[3] Maile R Brown, et al. J Neurophysiol. Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons

[4] Marcelo D Rosato-Siri, et al. J Pharmacol Exp Ther. A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons

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Keywords: AUT1, AUT-1 supplier, Potassium Channel, inhibitors

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