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CLP290

Cat. No. M9423
CLP290 Structure
Synonym:

CLP-290

Size Price Availability Quantity
10mg USD 155  USD155 In stock
25mg USD 275  USD275 In stock
50mg USD 445  USD445 In stock
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Quality Control
Biological Activity

CLP290 is a novel, orally available KCC2 modulator, highly selective for KCC2 over related Cl- transporters. CLP290 can significantly lower blood arginine-vasopressin (AVP) and glucose levels in STZ rats.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 404.46
Formula C19H21FN4O3S
CAS Number 1181083-81-7
Purity 98.09%
Solubility DMSO ≥ 25 mg/mL
Storage at -20°C
References

[1] Kim YB, et al. Diabetes. Excitatory GABAergic Action and Increased Vasopressin Synthesis in Hypothalamic Magnocellular Neurosecretory Cells Underlie the High Plasma Level of Vasopressin in Diabetic Rats.

[2] Ferrini F, et al. Sci Rep. Enhancing KCC2 function counteracts nnσгρh ιnё-induced hyperalgesia.

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Keywords: CLP290, CLP-290 supplier, Potassium Channel, inhibitors

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