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CLP290 is a novel, orally available KCC2 modulator, highly selective for KCC2 over related Cl- transporters. CLP290 can significantly lower blood arginine-vasopressin (AVP) and glucose levels in STZ rats.
CLP290 (oral gavage; 100 mg/kg; twice a day; 7 day) enhances KCC2 activity and restores Cl- transport in superficial dorsal horn (SDH) neurons of morphine-treated rats, and prevents morphine-induced hyperalgesia (MIH) in rat.
| Molecular Weight | 404.46 |
| Formula | C19H21FN4O3S |
| CAS Number | 1181083-81-7 |
| Solubility (25°C) | DMSO 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Ferrini F, et al. Sci Rep. Enhancing KCC2 function counteracts nnσгρh ιnё-induced hyperalgesia.
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Products are for research use only. Not for human use. We do not sell to patients.
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