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Tannic acid

Cat. No. M14262
Tannic acid Structure
Size Price Availability Quantity
500mg USD 40  USD40 In stock
1g USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM.

Chemical Information
Molecular Weight 1701.2
CAS Number 1401-55-4
Solubility (25°C) Water ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xiao Liang, et al. Tannic acid-fortified zein-pectin nanoparticles: Stability, properties, antioxidant activity, and in vitro digestion

[2] Rana A Youness, et al. Recent Advances in Tannic Acid (Gallotannin) Anticancer Activities and Drug Delivery Systems for Efficacy Improvement; A Comprehensive Review

[3] Min He, et al. Tannic acid/Mg 2+-based versatile coating to manipulate the osteoimmunomodulation of implants

[4] Gayong Shim, et al. Tannic acid-functionalized boron nitride nanosheets for theranostics

[5] K T Chung, et al. Tannins and human health: a review

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