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Tetraethylammonium chloride

Cat. No. M10624
Tetraethylammonium chloride Structure
Synonym:

TEACl

Size Price Availability Quantity
10mM*1mL in DMSO USD 40  USD40 In stock
1g USD 40  USD40 In stock
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Quality Control
Biological Activity

Tetraethylammonium chloride is a non-selective potassium channel blocker with antitumor properties. Tetraethylammonium (20 and 40 mM) increased the generation of intracellular ROS in C6 and 9L cells. In vivo, Tetraethylammonium (1 mM, 3 mM, and 5 mM) significantly increases the amplitude and frequency of contractility of colon and rectum from rats in longitudinal and circular direction.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 165.7
Formula C8H20ClN
CAS Number 56-34-8
Purity >98%
Solubility Water 100 mg/mL
DMSO 90 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Zhe Li, et al. Naunyn Schmiedebergs Arch Pharmacol. Tetraethylammonium enhances the rectal and colonic motility in rats and human in vitro

[2] K B Yang, et al. Chemotherapy. Tetraethylammonium inhibits glioma cells via increasing production of intracellular reactive oxygen species

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Keywords: Tetraethylammonium chloride, TEACl supplier, Potassium Channel, inhibitors

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