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Charybdotoxin TFA

Cat. No. M10575
Charybdotoxin TFA Structure
Size Price Availability Quantity
1mg USD 248  USD248 In stock
5mg USD 720  USD720 In stock
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Quality Control
  • Current batch:
  • Purity >97%
  • COA
  • MSDS
Biological Activity

Charybdotoxin TFA, a 37-amino acid peptide, is a K+ channel blocker.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 4409.91
Formula C176H277N57O55S7.C2HF3O2
CAS Number 95751-30-7 (free base)
Purity >97%
Solubility Water
Storage -20°C, protect from light, sealed
References

[1] M L Garcia, et al. Am J Physiol. Charybdotoxin and its effects on potassium channels

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Keywords: Charybdotoxin TFA supplier, Potassium Channel, inhibitors

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