Free shipping on all orders over $ 500

BMS-191011

Cat. No. M9394
BMS-191011 Structure
Size Price Availability Quantity
5mg USD 60  USD60 In stock
10mg USD 90  USD90 In stock
50mg USD 358  USD358 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

BMS-191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). BMS-191011 acts as a neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 370.71
Formula C16H10ClF3N2O3
CAS Number 202821-81-6
Purity >98%
Solubility DMSO ≥ 35 mg/mL
Storage at -20°C
References

[1] Romine JL, et al. J Med Chem. 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR.

Related Potassium Channel Products
L-Palmitoylcarnitine

L-palmitoyl carnitine is a long-chain acylcarnitine and fatty acid metabolite that accumulates in the sarcoid during ischemia and disrupts the membrane lipid environment. L-palmitoylcarnitine inhibits KATP channel activity by interacting with Kir6.2 without affecting single channel conductance.

OR-1896

Or-1896 is an active longevity metabolite of Levosimendan. Or-1896, a highly selective phosphodiesterase (PDE III) inhibitor, is a powerful vasodilator.

Tetraethylammonium chloride

Tetraethylammonium chloride is a non-selective potassium channel blocker with antitumor properties.

Charybdotoxin TFA

Charybdotoxin TFA, a 37-amino acid peptide, is a K+ channel blocker.

AUT1

AUT1 is a Kv3 potassium channel modulator which increases whole currents mediated by human Kv3.1b and Kv3.2a channels, with a concomitant leftward shift in the voltage-dependence of activation, while having a less potent effect on hKv3.3 currents.

  Catalog
Abmole Inhibitor Catalog




Keywords: BMS-191011 supplier, Potassium Channel, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.