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GAL-021

Cat. No. M14253

All AbMole products are for research use only, cannot be used for human consumption.

GAL-021 Structure
Size Price Availability Quantity
5mg USD 140  USD140 In stock
10mg USD 210  USD210 In stock
50mg USD 630  USD630 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

GAL-021 is a potent BKCa-channel blocker. GAL-021 inhibits KCa1.1 in GH3 cells. GAL-021 is a novel breathing control modulator that is based on selective modification of the almitrine pharmacophore. GAL-021 increases minute ventilation in rats and non-human primates.

Chemical Information
Molecular Weight 254.33
CAS Number 1380341-99-0
Solubility (25°C) DMSO ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Te-Ling Lu, et al. High Efficacy by GAL-021: A Known Intravenous Peripheral Chemoreceptor Modulator that Suppresses BK Ca-Channel Activity and Inhibits IK(M) or Ih

[2] Marijke Hyke Algera, et al. Opioid-induced respiratory depression in humans: a review of pharmacokinetic-pharmacodynamic modelling of reversal

[3] Francis J Golder, et al. Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator

[4] Mark L Dallas, et al. GAL-021 and GAL-160 are Efficacious in Rat Models of Obstructive and Central Sleep Apnea and Inhibit BKCa in Isolated Rat Carotid Body Glomus Cells

[5] J F McLeod, et al. GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers

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Keywords: GAL-021 supplier, Potassium Channel, inhibitors, activators

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