| Cat.No. | Name | Information |
|---|---|---|
| M4973 | BAPTA-AM | BAPTA-AM is a selective, membrane-permeable calcium chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively. |
| M2181 | ML133 hydrochloride | ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. |
| M3456 | Chlorpromazine hydrochloride | Chlorpromazine hydrochloride is an antagonist of D2, 5HT2A, potassium and sodium channels. The Ki of Chlorpromazine Hydrochloride to D2 and 5HT2A were 363 nM and 8.3 nM, respectively. Chlorpromazine also excites the 20S proteasome. *The compound is unstable in solutions, freshly prepared is recommended |
| M7029 | Nigericin sodium salt | Nigericin (NSC 292567) sodium salt is a selective K+ ionophore, Nigericin sodium salt is also an NLRP3 activator which can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes. |
| M20428 | Retigabine 2HCl | Retigabine is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels. |
| M9780 | Nigericin | Nigericin is an antibiotic derived from Streptomyces hygroscopicus, it acts as an H+, K+, Pb2+ ionophore. |
| M19123 | Citronellal | Citronellal is a monoterpenea from the essential oils in various aromatic species of plants, it attenuates mechanical nociception, mediated in part by the NO-cGMP-ATP-sensitive K⁺ channel pathway. Citronellal has depressant, and antinociceptive properties. |
| M14264 | VU0134992 hydrochloride | VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 µM. |
| M14260 | Quinidine hydrochloride monohydrate | Quinidine hydrochloride monohydrate is an anti-arrythmic agent which is also a potent blocker of K+ channel with an IC50 of 19.9 μM. |
| M14259 | Pinacidil | Pinacidil is a potent activator of potassium channel. |
| M14256 | JNJ 303 | JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. |
| M14255 | IK1 inhibitor PA-6 | IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. |
| M14252 | Apamin TFA | Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity. |
| M11045 | OR-1896 | Or-1896 is an active longevity metabolite of Levosimendan. Or-1896, a highly selective phosphodiesterase (PDE III) inhibitor, is a powerful vasodilator. |
| M8124 | Quinine hemisulfate salt monohydrate | Quinine hemisulfate salt monohydrate is a potassium channel inhibitor that inhibits voltage pulse-induced currents in the MT mSlo3 (KCa5.1) channel +100 mV with an IC50 of 169 μM.In addition, Quinine hemisulfate salt monohydrate binds to purine nucleoside phosphorylase (PfPNP) with low nanomolar affinity. In addition, Quinine hemisulfate salt monohydrate binds to purine nucleoside phosphorylase (PfPNP) with low nanomolar affinity. |
| M7936 | Mephetyl tetrazole | Mephetyl tetrazole is a potent, selective Kv1.5 potassium channel blocker with an IC50 value of 330 nM that selectively prolongs atrial effective response period (ERP) but has no effect on ventricular ERP. |
| M7706 | Chromanol 293B | Blocker of the slow delayed rectifier K+ current via KCNQ1 channels. |
| M6908 | Linopirdine dihydrochloride | Linopirdine dihydrochloride is a Kv7 (KCNQ) channel blocker. |
| M6634 | Cromakalim | Cromakalim is a kir6 (KATP) channel opener. Cromakalim relaxes rabbit isolated portal vein with an IC50 value of 21 nM. Cromakalim is potent, orally active and hypotensive in vivo. |
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